Egg Donation & Gestational Surrogacy
“Infertile couples from all over the world come to St. Louis, Missouri, to chase their dream, because Dr. Sherman Silber and his team are simply the best there is.” – Discovery Health Channel Documentary
(YOU CAN GET PREGNANT EVEN AFTER MENOPAUSE)
FIGURE 3: The decreasing follicle pool and age-related decline in female fertility.
While I have written that it is easier to get pregnant when you’re younger than when you’re older, we have developed a wonderful new method for getting pregnant with your own eggs even at an older age. I have urged women in their thirties not to delay high-tech treatment until it is too late. I’m going to turn around completely now and point out that if you have completely run out of eggs it is really still not too late to have a baby. All that is needed is an egg donor, and you can still carry your baby in your late forties or fifties, or even sixties.
I recently saw a woman in her forties who first got pregnant seventeen years ago, and because she was not married had an abortion. She went on the birth control pill for ten years and finally fell in love and had a happy, stable marriage. She had been trying unsuccessfully to get pregnant in that marriage for six years. She had irregular, occasional periods and was clearly about to go into menopause. We tried our best IVF & Mini IVF protocols but she just was completely out of eggs. When I delicately suggested the idea of giving up on her eggs and using a donor, she surprised me with her complete absence of anguish. She jumped up with excitement and told me immediately that she had two or three very good friends in mind who were in their early thirties who she felt would be happy to donate. Sometimes one can find close friends or younger sisters who are more than happy to donate an egg. However, in the vast majority of cases we have to find and match egg donors for such patients. This is not difficult for us to do and the wait is never more than 3 months.
NATURE VS NURTURE
Naturally, if you receive a donor egg, the genes of the baby will be a combination of your husband’s genes and those of the woman who donates the egg, even though you will carry the baby for nine months and deliver it. What are the psychological consequences of your carrying a baby that is genetically not your own? In fact how will the baby develop regarding personality., intelligence, character, emotional competence? This has been asked since 1983, when the first case was reported in Australia. I can say unequivocally that carrying that baby for nine months results in a solid, loving bond between the mother and the child, regardless of the genetic origin of the donated egg. Donor eggs never have led to any problems, in our experience. The fact that the child has been carried for nine months in the uterus results in solid bonding between mother and baby, regardless of the genetic origin of the egg, and this results in a child that is just like your own.
Most of the development of personality, character, intelligence , emotional security, and even athleticism begin with the parent in the first three years of life. The DNA is just the house the person lives in. But the person which that baby becomes, develops in the earliest months and years of life. He or she is learning those first several years and their brain is developing faster than any other times in their lives. They BLANK personality develops independent of their DNA. The wives naturally understand this and no donor eggs are no problem after they think about it and the men have no issue because it is their sperm anyway. Of course everyone wants their child to have their DNA, not a stranger. That is why we have become so good at helping older women and women with very few eggs get pregnant with their own eggs. But in some cases the woman is simply out of eggs completely. When that is the case, donor eggs are a very good (though at first strange seeming) option.
IT IS THE AGE OF THE DONOR AND NOT THE AGE OF THE RECIPIENT THAT MATTERS
Much older women (late forties and fifties) have no difficulty getting pregnant (greater than a 50 percent pregnancy rate per cycle) so long as the donor eggs come from young women. The age of the uterus is not what is significant in the high pregnancy rate of these patients, but rather the fact that: 1) the eggs came from healthy younger women, and 2) the recipient’s only infertility problem was that she had run out of fertile eggs. With these two operative factors, pregnancy rate using IVF and donor eggs in menopausal women is over 50 percent per transfer, and when frozen extra embryos are BLANK with BLANK over 95%, no different than what one would expect in younger women. The main determinant of pregnancy rate is the age of the woman from whom the eggs originate.
Women as old as sixty-three years of age have gotten pregnant quite easily with egg donation and have delivered healthy, happy babies. The oldest mother on record was reported by Dr. Richard Paulson in April of 1997. Dr. Paulson normally will not perform egg donation for women over fifty-five years of age, but this healthy-looking sixty-three-year-old woman successfully lied in order to get into the program. Although she was only two years away from being eligible for Medicare, she had no trouble conceiving and carrying the pregnancy normally because the eggs came, of course, from a younger woman.
Many of these older women getting pregnant with egg donation have multiple and often large fibroids in the uterus. These fibroids completely distort the uterine shape, and in prior decades they were thought to be a cause of infertility. On the basis of the ease with which these women become pregnant with donor eggs and deliver healthy babies, it is now apparent that the vast majority of uterine fibroids, no matter how large, have no effect on a woman’s fertility, and should not be overzealously operated upon. In fact, the only fibroids that should be removed for fertility are those that are indenting the cavity of the uterus. But removing fibroids is an easy operation and certainly can be removed before the embryos are transferred, again it is the age of the egg that matters.
Many women in their late 30’s and early 40’s who have run out of fertile eggs initially resist adamantly the suggestion of using donor eggs. They may insist on going through one unsuccessful IVF cycle after another, unwilling to even consider donor eggs. Eventually, years later, most of these women request donor eggs. Many of these women become like personal “friends” of the clinic because we come to know them so well. Despite years of negative feelings about the idea, all of them are overjoyed when they finally have a baby via donor eggs. We have no unhappy experiences with this.
FIND THE DONOR
It is not difficult with nationwide screening to quickly find at the right donor for you, that you will be happy with. There are a variety of outstanding agencies we work with, which allow you to find your right match. One extremely odd seeming application of donor eggs I saw recently, was a 44 year old woman who had a female child when she was 23 years old, decide not to abort her and raised a beautiful girl who is now 21 and going to law school. Her 44 year old single mother raised her beautifully and finally now is in a loving relationship, married to a 38 year old man, but she has run out of eggs. So the 21 year old daughter wants to help her mother and offered to donate her young eggs. Detailed psychological counseling revealed there was no confusion emotionally that it would be her mother’s baby and this is another happy case of egg donation.
it is usually better for this to be anonymous. The egg donor should not know who the recipient is and vice versa. This is your baby and the egg donor is making nothing more than a donation. The donor feels better that way and the recipient also does. This privacy is guaranteed by law and also guarantees that the “intended” mother is the mother no matter where the egg came from.
Another approach is for patients to search among their younger friends or relatives for someone who is willing to donate an egg, to make all the legal arrangements privately with them, and then to go through a screening and counseling evaluation. This is a “non-anonymous” program, and no one is being paid, but rather the gift is being made as an act of love. This requires very careful psychological discussions to ensure everyone knows who the mother is and it is not the friend or relative making the donation.
IS IT ETHICAL?
Our first egg donation case in the mid-80’s prompted consternation by some administrators and “ethicists” who feared the future, but was endorsed enthusiastically by the patients, their doctors, their parents and grandparents, and even the clergymen who represented the patients. A 28 year old woman had lost both of her ovaries as a teenager because of surgery for benign ovarian cysts. Her 24 year old sister had always felt sorry and guilty that she would be able to have children, and her older sister would not. She and her family brought the idea up to us of egg donation and despite some concern and trepidation, it felt right to me. This was the beginning of what has been one of the most personally and emotionally rewarding aspects of my medical practice. The sister with no ovaries conceived healthy twins who are now grown and happy young women, who might not exist today if we had reacted negatively to this unusual sounding first request.
A year later we were challenged once again to ponder the ethics of an even more complicated patient request. A 40 year old woman who was a very prominent lawyer had run out of eggs, and was married to an equally prominent lawyer who had no sperm. They were real experts on family law. They desperately wanted a child and preferred to preserve the genetic lines of their family. He had one younger sister and she had one brother. Her brother offered to donate sperm, and his sister offered to donate eggs. Thus the embryos generated by his wife’s brother’s sperm and his sister’s eggs, allowed them to continue their family line, and yet avoid consanguinity.
I was confronted years ago by a nurse who had gone through menopause early, was now 42 years old, and who strongly wanted to have a child with her husband knowing full well that it would require donor eggs. Yet she was very intellectually bothered by the idea of bringing technology into the process of getting pregnant. She was a very deep and “new age” spiritual person who just feared the mingling of technology and conception. I remember telling her to read “Zen and the Art of Motorcycle Maintenance”. She was surprised that a conservative physician would have even read such a book, but our bond of trust as doctor and patient was immediately sealed. She and her husband now have a gorgeous and intelligent daughter, and it matters not to her or her husband that the conception was the result of technology.
HOW IS IT DONE?
So how do you find the right donor, and what are the requirements? Occasionally, a friend or relative works if there is very careful, in-depth counseling and psychological questioning. We have never had a problem with such cases, but will turn them down if there is the slightest chance of confusion on who is the mother, just as the law dictates, the intended parent is the parent, that has to be deeply, psychologically, a firm conviction.
Usually however we will connect you with very reputable agencies that will help you find the right match for you and you even have an abundance of choices. It is amazing how many bright young women there are who would like to anonymously help women who have run out of eggs have a baby. They will be carefully checked for genetic history and ethnic origin, and once you make your choice we still have veto power if we feel you may have made a poor choice. But usually these are the bright young (most under 30) women who want to help and so we rarely find couples making a poor choice.
We need to talk further about the technical aspect of: 1) synchronizing the cycles of the donor and the recipient, and 2) giving the proper hormone replacement to recipients so that their uterus is prepared for implantation of the embryo and also to maintain the pregnancy until such time as the placenta starts making its own hormones by eight to twelve weeks of pregnancy.
It is all timed out with the same goal in mind, that the recipient first receives proper estrogen priming of her uterus, and then one day after the donor receives her HCG injection the recipient begins taking progesterone injections in addition to the estrogen. This assures that the IVF transfer will be performed at that time in the cycle where the window of receptivity for egg implantation is open. Between day four and day six of progesterone replacement is when the day 3 embryo must be placed into the uterus.
Even after it is clear that you are pregnant you will have to stay on estrogen and progesterone supplements for up to twelve weeks longer, until the normal time in pregnancy when the placenta takes over the function of the ovary and produces all of its own self-sustaining estrogen and progesterone. This may require considerably less than twelve weeks, and the latest data indicate that by six weeks (contrary to our previous thinking) the placenta may be making enough estrogen and progesterone to sustain the pregnancy. The way to determine that is to get blood tests every week for estrogen and progesterone levels, and when the progesterone level begins to rise dramatically over what we know you’re getting from replacement, then we know the placenta has taken over and you no longer need to take hormone replacements. However, most infertility physicians, including me, feel safer if you stay on the estrogen and progesterone for a full three months just to be safe.
DOES EGG DONATION HURT OR RISK FERTILITY IN THE FUTURE OF THE DONOR?
The simple answer is no. Donating eggs has no negative effect on your future fertility. The reason is the that all women have a storehouse of immature eggs in the outer ring of their ovary, usually about six million in the female fetus, about 2 million at birth, 400,000 by their teen years. Every month in young women, about 1,000 eggs leave this primordial pool, and this is inexorable. No hormones or any treatment can stop this loss of primordial follicles every month which develop eventually into antral follicles and one of which will eventually ovulate, and the other 999 will die as a normal part of the menstrual cycle. This is a normal part of gradual egg loss in all women as they get older. So when you donate say 5 eggs, they all would have died anyway so you lose no eggs at all by egg donation.
Are there other risks to the donor? Well of course if you go to a poor or mediocre clinic to donate your eggs then you could have risks of a poorly done egg retrieval, hyper stimulation syndrome or anesthetics risks. But none of those should be a problem, if you donate to a good clinic.
WHAT DOES EGG DONATION COST?
Most egg donors go through an agency to guarantee anonymity. These women usually have purely altruistic intentions but to make certain their good intentions are not abused the agency will pay them between $2,000 and $7,000 dollars, depending on their age and other demand factors. After agency and legal fees are paid, it can add up to $10,000 dollars over the cost of regular IVF, which can cost $9,000 to $12,000 dollars. But the success rate is so high, especially considering these are patients who otherwise have no eggs, that the expense is worth it. Again, to maintain absolute anonymity, the patient recipient pays the agency and the agency pays the egg donor. We have never yet had an unhappy story coming out of an anonymous egg donation to women who have simply run out of eggs.
How to Get Pregnant
by Sherman J. Silber
completely revised and updated (2007)
Mid-Rivers News Magazine, October 26, 2011
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In 1980, I received a very sad letter from a 25 year old woman in the Bronx, New York, saying that when she had surgery for uterine fibroids, the doctor had to perform a hysterectomy, and she lost her uterus. Now she desperately wanted to have children. Unfortunately, at that time, I had to write to tell her there was no hope. I had predicted in my original book in 1979 that with the “new” in-vitro fertilization technology on the horizon, perhaps at some time in the future a woman without a uterus could have someone else carry her genetic child for her. But by the time this futuristic medical prediction became a reality, this lady had already run out of eggs and was in menopause. (Of course today we can solve that problem, too, as you have seen in the first part of this section). It is a readily available, beautiful solution in the U.S.
HISTORY OF GESTATIONAL SURROGACY
In 1985, Dr. Wolf Utian and Dr. Leon Sheehan from Cleveland reported the first successful case whereby a woman with no uterus whatsoever was able to have her own genetic child. The story of that first case, reported in the New England Journal of Medicine, was absolutely spellbinding: A thirty-seven-year-old woman became pregnant, but the uterus spontaneously ruptured at twenty-eight weeks of gestation, necessitating a cesarean section and a hysterectomy. The baby girl subsequently died and the woman was left childless and without a uterus. The couple, however, remained strongly committed to having their own genetic child and the wife asked that an embryo of hers be transferred to the uterus of a friend who was interested and willing to carry the child as a surrogate. The friend was a healthy, married young mother of two. The reproductive cycles of the two women were synchronized (this will be explained later). The patient’s eggs were incubated with sperm from the husband, and three days later an eight-cell embryo was transferred to the uterus of the surrogate. The surrogate became pregnant and nine months later delivered the healthy genetic baby of her ecstatic friend.
At the American Fertility Society meeting in 1986, a lady introduced herself to me and thanked me for the prediction that I made in my original book about gestational surrogacy. She told me it had prompted her to go to the in-vitro fertilization program in her community where she told them what she would like. Performing this kind of procedure is so simple that it turned out not to be a problem, and indeed, when I saw her at that meeting, her best friend was already pregnant with her genetic baby and ready to deliver and give it to her.
CASE HISTORIES OF GESTATIONAL SURROGACY
A few years later I took care of a famous pair of sisters who were written up in Good Housekeeping magazine. Linda had gone through many failed attempts at in vitro fertilization in other clinics. Her sister had already had several children without any problem and was quite willing to carry a baby for her. We were able to obtain six embryos from Linda’s eggs and her husband’s sperm. We put three embryos into Linda and three embryos into her sister, so as to hedge our bets. As it turned out, both sisters conceived, one with twins and the other with a singleton. The twins were born in December, and the singleton was born in January of the subsequent year. Thus triplet siblings were born safely in different cities and in different years. The surrogate sister, of course, gladly gave the children back to their genetic parents. She has always felt a very deep and close relationship, as a special kind of aunt, to the niece and nephew she carried for their mother.
We were approached by a 29 year old woman who had her uterus and both ovaries removed, and desperately wanted to have a child. Her husband had perfectly normal sperm, and they both wanted a baby by her husband’s sperm. The question for this patient is who would provide the eggs and who would provide the uterus? In her family, one of her sisters was willing to donate an egg, the husband of course would provide his sperm, and another sister would allow the eggs and the sperm to be transferred to her so that she could carry the baby. This couple now has a beautiful daughter, with two special aunts, one who provided the eggs, and one who carried her. Thus, with an open attitude, and loving friends and family who are willing to help, virtually anybody can have a baby.
WHAT IS THE LEGAL PROTECTION?
Laws ensure that if a woman carries her own genetic baby as a surrogate for another couple, she does not have to give it up involuntarily. If it is her genetic baby, then she has every right to it. The egg must come from a source other than the surrogate, therefore a surrogate for another couple must not be the egg source also. That is, to be a surrogate, a woman must not be the genetic mother. Similarly, if there is an egg donor, the egg donor must not also be the surrogate. The common laws are very consistent with what makes biological and psychological good sense and completely protects the intended parent and the surrogate. If the surrogate was also the egg donor there would be a severe danger of psychological “bonding” conflicts, regardless of the original intent of the would-be parents and the surrogate. However, as long as the egg donor and the woman carrying the baby are different, we have never seen such a conflict.
One of our earliest surrogate cases was a 27 year old woman who had lost her uterus from a hysterectomy necessitated by severe bleeding occurring in her previous pregnancy. The only way the doctors could save this young woman’s life from this obstetric disaster was to remove her uterus. Yet she had normal ovaries and her husband had good sperm. What was the solution? As it turned out, her 48 year old mother was quite willing to serve as a surrogate uterus to carry her daughter’s baby. Their menstrual cycles were synchronized with birth control pills so that day one of the mother occurred simultaneously with day one of the daughter. The daughter was stimulated in the usual fashion for in vitro fertilization, her eggs were fertilized with her husband’s sperm, and her embryos were transferred into her mother’s uterus. Astoundingly, the 48 year old mother became pregnant with her daughter’s twins. Nine months later, she gave birth to two healthy grandchildren whom she then immediately turned over to her daughter and son-in-law.
The common legal and psychologically sound theme behind all this is that the “intended parent” is the parent, no matter where the eggs come from. Whether it is an egg donor for a woman who has run out of eggs, or is a surrogate carrying the baby from an embryo of a woman who has eggs, but no uterus, it is the “intended parent” that is the parent.
ETHICS AND LEGALITY OF GESTATIONAL SURROGACY
Surrogate uterus pregnancies are here to stay; they are morally and ethically completely proper, and they offer an opportunity for a relative or a loved one to give the greatest gift possible to a woman without a uterus. One 40 year old patient of ours had already gone through four cycles of IVF elsewhere and failed to get pregnant. All of her doctors recommended that she give up, but she refused. She had gone through 14 years of infertility treatment for bilateral tubal infections and “clubbed” tubes. Her main problem was that women with blocked fallopian tubes caused by infection are known to have lower pregnancy rates with IVF. There are many theories to explain this, including the possibility of retained toxic fluid in the blocked tubes, or even that some permanent but subtle damage has been done to the uterus by the infection. This woman had her tubes removed just to make sure that the former was not a problem. Nonetheless she failed to get pregnant with four IVF treatment cycles in another center and in her fifth IVF cycle with us. It was natural to attribute the fifth failure to her biological clock, since she was forty years old and pregnancy rates in forty year olds are much lower with IVF.
However, on the chance that her problem all along might be related to her history of tubal infection, her husband’s cousin (who had already had five normal pregnancies and five children and whose husband was vasectomized so they could not have anymore children) agreed at age 42 to be a surrogate for this patient. Our 40 year old patient had such a poor ovarian reserve by this time (after 14 years of trying to have children she was just about at the end of her (biological clock) that we were only able to obtain two embryos. We transferred both of those embryos into her husband’s cousin and warned them that the prognosis was extremely poor. Nonetheless her cousin did become pregnant and delivered a healthy little baby girl nine months later. Despite the woman’s vastly reduced ovarian reserve after so many years of unsuccessful treatment, the problem all along was simply that because of prior infection her uterus was not receptive to implantation.
We’ve had many similar cases whereby the history of prior tubal disease has conferred a low pregnancy rate on couples, and after many failed attempts at pregnancy with IVF (to bypass the tubal blockage), resorting to a surrogate, who is usually a family member or close friend, solved the problem. Although removal of the fallopian tubes in these patients may improve their pregnancy rate with IVF, often it doesn’t. In women who have diseased fallopian tubes, if they don’t get pregnant on their own with several cycles of IVF, using a surrogate will be a simple solution to the problem.
In some cases it would be medically inadvisable for the patient to carry her own child, such as the Marfan’s syndrome patient I discussed in detail in a previous chapter. This was a woman who had a genetic disease that required her to have heart and blood vessel operations to protect her from sudden death, and who had to be on blood thinners because of these operations. A pregnancy for her would be fatal. Thus when she got married her mother came forward and offered to carry her babies for her. Not only was she able to safely have twins which her mother carried (i.e., her mother carried her own grandchildren), but we were able to perform genetic diagnosis on those embryos to make sure that neither of these two babies, which her mother carried, would have the risk of the same genetic disease that she had inherited from her father.
HOW IT IS DONE
Although the gestational surrogacy procedure is medically simple (now that you have read the rest of this section, and understand how IVF technology works), I will outline the methods we use for synchronizing the cycles of the donor and recipient. This work had been going on for decades in cows before we applied it to humans. Embryos from highly prized cattle would be placed into the uterus of very low milk-producing cows, who would then give birth to prize heifers. Since embryos could be obtained every month, a prize cow could deliver twelve heifers a year via the uterus of surrogate cows rather than just one prize heifer a year. This vastly improved the efficiency of milk production in the world. Every time you go to the grocery store and notice how relatively inexpensive nature’s most perfect food (milk) is, realize that it is partly because of these reproductive advances.
In humans, the synchronization is a little more difficult than in cows. Both women are placed on birth control pills. These pills, started in the beginning of the follicular cycle, put the women “on hold” and can be discontinued at the same time for both of them. The key factor in synchronizing the cycles of donor and recipient is that the recipient must start on progesterone injections one day after HCG is given to the donor. The purpose of synchronizing the donor and recipient is that the endometrial lining of the recipient must be at the stage of development in the monthly cycle where it is receptive to implantation of the embryo at its stage of development.
You will see our protocol for synchronization, whether it involves a surrogate uterus or an egg donor, two clinically opposite situations. For both situations, this synchronization schedule works quite reliably. Both the donor and recipient are put on birth control pills to synchronize their cycles. The recipient also goes on Lupron so as to completely suppress her pituitary. On the first day the donor receives gonadotropin, the recipient starts on Estrace (an oral, absorbable form of natural estrogen). The recipient’s Estrace dose is 6 mg per day. Often an estrogen patch is also used to guarantee that an adequate uterine lining forms. The length of the artificial follicular phase during which the recipient is on Estrace and the patch is not important; the only significant factor is when she goes on progesterone. Whenever the donor receives HCG, which is often (but not always) on the tenth to twelfth day after gonadotropin has begun, the recipient starts on progesterone one day later.
This always allows the synchronization to time out perfectly for embryo replacement into the recipient. Keep clearly in mind that the donor-recipient synchronization is exactly the same whether this is the case of gestational surrogate recipient, or in reverse, of a donor giving eggs to a patient with a uterus who has no viable eggs of her own.
Please recognize that legally you are completely protected, whether using donor eggs or gestational surrogates. The reason is that the basic rule is that the intended parent is the parent. So therefore, whether you are using a donor egg from someone else, or you are putting your eggs into someone else’s uterus, the intended parent is always the legal parent.
How to Get Pregnant
by Sherman J. Silber
completely revised and updated (2007)
Mid-Rivers News Magazine, October 26, 2011
For more information on egg donation, please feel free to call us at (314) 576-1400.