Human Ovarian Tissue Vitrification

By SHERMAN SILBER

Cryopreservation of Mammalian Gametes and Embryos: Methods and Protocols,

Ashok Agarwal, Zsolt Peter Nagy and Alex Varghese

June 24, 2013

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Summary

Ovarian freezing and transplantation has garnered increasing interest as a potential way of preserving fertility in cancer patients as well as for women who just wish to delay childbearing.  This chapter spells out our techniques of ovarian cortex vitrification and results for frozen compared to fresh ovarian cortex transplantation (in one single series from one center for the sake of consistency), as well as potentially provide insight into the mechanism behind ovarian follicle recruitment [1-15]. This represents an effort to simplify and popularize an approach that has yielded favorable results (all cases recovered ovulation and 75% had successful spontaneous pregnancy) in one single, disciplined study. It should be clear that this is a review for the more general reader of our original scientific papers published in Reproductive BioMedicine Online, New England Journal of Medicine, Fertility and Sterility, Human Reproduction, and Molecular Human Reproduction.

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Nagy Chapter Figure 1 a-f

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