Dr. Sherman Silber, a renowned pioneer in microsurgery and infertility, is considered one of the world’s leading authorities on IVF, mini-IVF, sperm retrieval, ICSI, vasectomy reversal, male infertility, tubal ligation reversal, egg and embryo freezing, ovary transplantation and the reproductive biological clock.
For over 46 years Dr. Silber has personally developed originally most of the popular fertility treatments used around the world today.
He performed the world’s first microsurgical vasectomy reversal, as well as the first testicle transplant, in the 70’s and now in the current century, the world’s first ovary transplant. He was the first to develop the TESE and MESA techniques for retrieving testicular and epididymal sperm in azoospermic men. He headed the clinical MIT team that first mapped and sequenced the Y chromosome in infertile men and discovered the now famous DAZ gene for male fertility. His research includes also the study of reproduction and fertility in zoo animals and endangered species. Most recently he has perfected the preservation of fertility for cancer patients with ovarian freezing and transplantation and thereby figured out how to extend the reproductive biological clock of women. He has helped pioneer minimal ovarian stimulation to reduce IVF costs and eliminate complications while maintaining the very highest success rate, even in older women. He heads the clinical team on the CHOSE project to transform skin biopsy cells into eggs and sperm in humans. He has even recently answered the age-old question of why the dinosaurs went extinct by extending his research on male infertility and the Y chromosome, discovering that the change in earth temperature 65,000,000 years ago led to the birth of a skewed male/female sex ratio.
Dr. Silber has treated many thousands of infertile couples who travel to St. Louis daily from all over the world. His patients come from every state in the U.S.A., all over Europe, South America, the Middle East, Asia and Africa. His patients include doctors, teachers, rock stars, secretaries, politicians, astronauts, movie stars, scientists, truck drivers, lawyers, migrant fruit pickers, CEO’s, princes and kings.
He is the author of five medical textbooks, five best selling books for the layman and more than 250 scientific papers on human infertility and reproduction. His book, “How to Get Pregnant”, published by Little, Brown and Company in 2007, is a completely revised and updated edition of his classic series of “How to Get Pregnant” books, which have been major bestsellers. He recently published the definitive text on male infertility, “Fundamentals of Male Infertility”. Dr. Silber’s books have been published in English, Spanish, German, Russian, and Chinese (Mandarin). He has appeared many times on the Today Show, Good Morning America, the Donahue Show, Gary Collins, Peter Jennings ABC Nightly News, Oprah, Charlie Rose and Ted Koppel Nightline. He has been a consultant numerous times on the Joan Rivers Show and ABC News and has been a regular contributor many times on CNN, KMOX, WOR, and NPR radio.
Dr. Silber went to medical school at the University of Michigan, did post-graduate training at Stanford University, and then again at the University of Michigan. From 1967 to 1969, he provided medical care via the U. S. Public Health Service to Eskimos, Indians, and Aleuts. Then he taught at the University of Melbourne Medical School in Australia, and later at the University of California Medical School in San Francisco. He is a scientific collaborator at MIT in Cambridge, Massachusetts, at the Kato Clinic in Tokyo, and at the University of Kyushu in Japan, and is a full professor at the University of Amsterdam, and at Sun Yat Sen University Medical School in China. His major clinical medical practice is at St. Luke’s Hospital in St. Louis, Missouri.
His research now extends to making skin cells into stem cells and then into sperm and eggs in the human, collaborating with the University of Kyushu, UCLA and Pittsburgh University. They have the only such IRB for this work in the world, and are actually making great progress.
His most currently applicable innovation is IVM from ovarian tissue, using the basic knowledge on oocyte development learned from successful in vitro oocyte production (with successful offspring) in the mouse.
He always gives credit for his amazing surgical dexterity to the training he received during medical school from an uncertified but brilliant Black janitor who washed instruments at the animal lab at the University of Michigan. He honored his incredible surgical teacher on the NBC News Today Show in 2006.