Sherman J. Silber, MD. Director of The Infertility Center of St. Louis, Missouri. USA:
Studies show that if you are pregnant with COVID-19 there is no harm to the fetus. Careful scientific studies also show that certain drugs such as Chloroquine are extremely effective in treating the virus. In addition, experimental studies have shown that getting plenty of sleep can improve resistance to the virus. There are many myths and rumors about this virus, but the data below from well-established academic centers will detail the validity of the above statements. -Dr. Sherman Silber
“A Redbook Special Report: The Ultimate Fertility Guide”
Want to be pregnant, but aren’t? Read on for comprehensive, cutting-edge info on what your options are, where to go for help—and how to tell which treatment is best for you. By Toni Gerber Hope
Outstanding Infertility Centers
There are nearly 300 clinics affiliated with the Society for Assisted Reporductive Technology. How do you choose the best one for you? Start by collecting recommendations from doctors and others you trust, then ask probing questions before signing on with a facility. Also, Assisted Reproductive Technology Success Rates, a directory of data from centers across the country, can point you to clinics achieving higher-than-average pregnancy rates or treating a larger number of couples with particular problems. Based on the most recent directory figures, these ten centers stand out:
Reproductive Partners Medical Group Redondo Beach, CA: Higher-than-average success rates (women 39 and under); more extensive experience with ICSI.
Colorado Center for Reproductive Medicine Englewood, CO: Higher-than-average success rates in all age groups; especially noteworthy for 40 and up. Higher success rates using frozen embryos.
Cornell University Medical College, Center for Reproductive Medicine New York, NY: Large program with higher-than-average success rates for all age groups; higher success rates using frozen embryos; more extensive experience with ICSI.
Eastern Virginia Medical School, The Jones Institiute for Reproductive Medicine Norfolk, VA: Higher-than-average success rates using
frozen embryos (women under 40); larger number of patients with male-factor infertility; more extensive experience with ICSI.
Institute for Reproductive Medicine and Science, St. Barnabas Medical Center Livingston, NJ: Higher-than-average overall success rates; especially noteworthy for women 40 and older.
Mayo Clinic Assisted Reproductive Technologies Rochester, MN: Higher-than-average success rates for all age groups; higher success rates using frozen embryos.
New England Fertility Institute Stamford, CT: Higher-than-average overall success rates; especially noteworthy for women 40 and older.
NYU Medical Center, Program for IVF New York, NY: Higher-than-average success rates for younger women (under 40); higher success rates using frozen embryos.
Pacific Fertility Medical Center—San Francisco San Francisco, CA: Higher than average success rates, especially for women under 40.
Maybe you’ve just gotten married and have vague plans to start your family in a couple of years. Maybe you have one child and think you’ll have a second with the same ease. Or maybe you’re just beginning to wonder why—after three months of trying (or six or eight)—you’re not yet pregnant. Whatever your situation, know this: If you want a baby, you can’t assume it will just happen. As you’re reading this, some six million women and their husbands are facing infertility. They’re wondering what they need to do next to become pregnant, frustrated that they didn’t realize sooner just how big an impact age or medical problems were going to have on their lives.
No matter how much the word “infertility” is in the air, it is still a shock to realize that you are one of the ones who can’t just get pregnant when you want. First you may joke, “Guess I didn’t have to be quite so careful about birth control.” But gradually, you have to give up your fantasies—”we’ll have our child in June, so I can take the summer off”—and confront the fact that, for you to have a baby, it is going to take significant effort. As you undergo medical tests and treatments, a new techno-vocabulary dominates your life and a new self-image- patient -emerges. You have joined the 10 percent of U.S. couples who will experience infertility at some point in their reproductive lives.
The good news (if there’s anything good to be said about infertility) is that there is more real help available than ever before. But there is also a lot of incompetent treatment out there, not to mention hype. “Infertility care is a highly competitive, for- profit business,” points out Brian Kearney, Ph.D., a molecular geneticist and author of High-Tech Conception: A Comprehensive Handbook for Consumers. “You need to sort through what you hear and learn to ask the right questions.” Then, you can get the care that has the best chance of working for you.
WHY ISN’T IT HAPPENING? Given the exquisitely intricate orchestration of hormones and engineering it requires, it seems astonishing anyone ever has a baby. Your egg, triggered by release of just the right hormones, needs to mature in the ovary, be released into the fallopian tube, then be fertilized by a sperm, travel down the tube, and implant in the uterus, there to grow to a seven-pound baby. That stunning complexity shows how easy it is for a glitch in any part of the system to throw the process off. Some of these malfunctions may have been with you since birth; others are the legacy of infection, lifestyle, age, or, frustratingly, factors no one can explain. While there are dozens of causes of infertility (and, often, multiple reasons a couple can’t conceive), basically, these break down into a handful of categories:
OVULATORY DISORDERS Failure to ovulate consistently (or at all) or to produce eggs capable of being fertilized accounts for about one quarter of female infertility cases.
TUBAL PROBLEMS The fallopian tubes may be damaged or blocked, say by adhesions resulting from past infection (usually a sexually transmitted disease).
CERVICAL PROBLEMS Like Goldilocks’s porridge, the cervical mucus needed to help transport the sperm to the egg has to be “just right”: not too thin, not too thick, not too acidic.
UTERINE ABNORMALITIES The lining may not be thick enough for the egg to implant. Or you may have endometriosis, where, for unknown reasons, the lining of the uterus grows outside the uterus (in the fallopian tubes or abdominal cavity), possibly impairing the movement of the egg through the fallopian tube or causing hormonal or other disruptions.
MALE FACTORS These include a low sperm count, sperm of poor quality (perhaps abnormally shaped), low motility (sperm are too slow-moving), blocked or missing transport tubes (which prevents sperm from reaching the ejaculate), or absence of sperm altogether. There may also be a problem with the quality of a man’s semen, or there may be an infection.
It took the most advanced techniques of reproductive medicine—and a small coincidence—for Lori and Ken Kreher to become the parents of Blake Edward, born last January. In 1995, Ken, who has been a paraplegic since a 1989 construction accident, was working with a personal trainer, in hopes of making the U.S. Paralympics team. Learning that the Krehers desperately wanted a second child (daughter Kelli was 7 months old at the time of her father’s accident and, says Lori, “the only thing that kept Ken going then”) and that the method they were trying wasn’t getting them anywhere, the trainer suggested they contact another client of his,Sherman J. Silber, M.D., a prominent fertility specialist and director of the Infertility Center of St. Louis. In a remarkable technique, doctors were able to extract sperm directly from Ken’s testicle and fertilize Lori’s eggs through ICSI. The first attempt failed, but three months later, when doctors tried ZIFT (inserting five fertilized eggs into Lori’s fallopian tube), she became pregnant. “We just went wild,” says Lori. “It was such a good thing to finally happen.”
For about one in five infertile couples, however, no cause will be found, a condition known as “unexplained infertility.”
These problems can also kick in after you’ve had a child. Or a mild abnormality might become more severe, making it difficult~r impossible-to conceive again. Such “secondary infertility” can elicit the same feelings of disappointment and frustration, tinged perhaps by guilt that you’re not satisfied with having one child.
WHEN SHOULD YOU SEE A DOCTOR? Standard texts define infertility as the inability to become pregnant after one year of regularly timed, unprotected intercourse. But you don’t have to wait for it to be “official.” In fact, many fertility experts believe that at six months, you might start exploring whether something’s wrong.
That exploration is going to take time. For a start, your ob/gyn may have you chart your basal body temperature (the reading you get first thing in the morning) or use a home ovulation-prediction kit for three months, to see if you’re ovulating regularly. Then you can’t just schedule all your diagnostic tests and procedures for, say, the first week of December. Many of these tests (see chart at left) need to be timed to a specific day in your cycle, and can’t all be done in the same month. Add in nonmedical delays—you have to wait for approval from your HMO, your husband is traveling-and you could be eating up even more time.
Maybe this isn’t a problem if you’re in your twenties. But as you reach your mid-thirties, you’re looking at an increasingly narrow window in which to conceive—even narrower if you hope to have more than one child.
WHY AGE COUNTS SO MUCH At some point-if you’re struggling to conceive-you’ll probably find yourself muttering, “Bet if I were an unmarried teenager, I’d be pregnant by now.” Actually, you’d be on to something—not the marriage part, of course, but the youth. In your twenties, you have a 20 to 25 percent chance of becoming pregnant each month. By your forties, that drops to just 10 to 15 percent. Age is the factor that, almost always, will drive the decisions couples have to make about infertility treatments.
That is, your age—or, more precisely, the age of your eggs. When you’re born, your ovaries contain all the eggs you will ever have. Each month after you reach puberty, if things are working properly, a new egg will mature and be released, some 400 times in your lifetime. Generally, however, the most fertilizable eggs are released earlier in life, explains Sherman J. Silber, M.D., director of the Infertility Center of St. Louis at St. Luke’s Hospital and author of How to Get Pregnant with the New Technology.
The decline isn’t completely steady: “Throughout your twenties and early thirties, fertility drops gradually. But then, at 37, there’s a sharp falloff,” says Dr. Silber.
What about your husband? Because a man is continually producing new sperm—every day—his age doesn’t influence his fertility. But other factors do. Men who’ve had an STD may have blocked tubes, so sperm are unable to travel from the testes, where they’re manufactured, to the urethra, where they join the ejaculate. A man may also have been born without the necessary connecting tubes or be may have a genetically derived form of infertility. Lifestyle figures in, too: Alcohol, drugs, cigarettes, and a diet low in certain nutrients (zinc especially) have all been shown to lower sperm counts or cause sperm to become abnormally shaped.
IS YOUR GYNECOLOGIST GOOD ENOUGH? Chances are, when you first suspect a problem, you’ll turn to the ob/gyn you’ve been seeing for checkups. Certainly, the doctor should be able to get you started on figuring out what’s wrong—confirming ovulation, doing blood tests or other preliminary diagnostic procedures. He should also be able to refer your husband to a urologist for sperm tests and semen analysis. Make sure the urologist is one who specializes in male infertility, advises Theresa Venet Grant, president of INCIID (the InterNational Council on Infertility Information Dissemination), not a general urologist.
Many women stay with their gynecologists month after month, even for years. And that could be a big mistake—possibly the biggest one a couple makes. “The expertise of an infertility specialist can make the difference between years of infertility and successful pregnancy,” notes Diane Clapp, medical information director for Resolve, a national information and advocacy organization for couples experiencing infertility.
Part of the problem may be the training, but part can also be attitudinal, observes Christo Zouves, M.D., medical director of Pacific Fertility Medical Center in San Francisco. “Doctors may be resistant to suggesting high-tech approaches. They’ll approach infertility treatment with an attitude of ‘let’s try this, then this, then this…,’ not realizing that they’re using up precious time, especially if a woman is in her mid-thirties.”
When should you leave your ob/gyn for a specialist? If you’re 35 years or older, advises Clapp, or if you have any of the following difficulties:
YOUR MENSTRUAL CYCLE is irregular, with signs of irregular ovulation. YOUR HUSBAND’S SEMEN analysis reveals a low sperm count, low motility, or abnormally shaped sperm. YOU HAVE A HISTORY of a pelvic infection. YOU HAVE NOT BEEN ABLE TO CONCEIVE after two years, even though basic tests have come back normal.
Suppose your doctor assures you that he or she is a “fertility specialist”? There are some physicians who “practically invented the field,” says Grant, and who gained all their experience in practice, not in academic training. But unless you know that’s the case, you should look for a board-certified reproductive endocrinologist. If your ob/gyn can’t refer you to one, check The Official ARMS Directory of Board Certified Medical Specialists (available in public libraries) or write to Resolve at 1310 Broadway, Somerville, MA 02144 for a specialist in your area.
When you call a reproductive endocrinologist, make sure at least some of the staff and technicians are available seven days a week. “If they’re not,” says Grant, “you’re clearly not in the hands of someone whose priority is getting you pregnant.” After all, you may ovulate on a Saturday or Sunday, and need to be seen for tests or treatments pinned to that day. What’s more, if you have a regular 28-day cycle, the same thing will happen next month and the one after and…
The Hales knew shortly after they were married in 1991 that they were going to need IVF: Jennifer’s tubes, tests had shown, were completely blocked. What they didn’t know, though, was that Andrew also had a problem, something they learned three years later during their first IVF affempt, when only two out of a dozen eggs were successfully fertilized. Two more affempts (one with ICSI, one using frozen embryos) also failed. At that point, the Hales thought they might turn to adoption. But deciding to give IVF with ICSI one more shot, in 1997 they consulted the Pacific Fertility Medical Center in San Francisco. “This time we had an angel on our side,” says Jennifer. Last July 4, Julia Elizabeth Hale was born.
LOW-TECH ANSWERS For most couples, relatively noninvasive techniques will work:
FERTILITY DRUGS If diagnostic tests show that you have ovulation irregularities, your doctor will probably suggest that you try the drug Clomid (clomiphene citrate, also marketed as Serophene) and have scheduled sex based on when tests show you’re about to ovulate. (“If your doctor simply throws Clomid at you without any testing,” says Dr. Silber, “find another doctor.”)
This is an okay game plan for a limited number of months, up to six, some suggest. Others say even fewer. “If Clomid is going to work,” says Dr. Zouves, “it will do it in three cycles.” Unfortunately, there are doctors who will urge women to keep trying with Clomid, sometimes up to a year—a suggestion that not only won’t help, but could expose you to unnecessary danger, says Carolyn Runowicz, M.D., director of the division of gynecologic oncology at the Albert Einstein College of Medicine and Montefiore Medical Center in New York. (Some studies have shown a link between fertility drugs and ovarian cancer, but until we know—the National Cancer Institute is carrying out long-term studies now—caution seems prudent.)
If Clomid doesn’t work, your doctor may suggest using more powerful ovulation-induction drugs—such as Pergonal (known chemically as hMG, for human menopausal gonadotropin) or Fertinex (chemically, FSH, for follicle-stimulating hormone) to be taken by injection at home. While you’re on these drugs, you need to be monitored with blood tests to make sure hormone levels are rising properly. A few days into treatment, you should also have a transvaginal ultrasound (a sonogram done with a probe inserted vaginally) to check that follicles in your ovary are maturing. Ultrasound is also necessary to check that your ovaries are not becoming enlarged or producing too many follicles—which may lead to a potentially dangerous condition known as ovarian hyperstimulation syndrome.
All these drugs, but especially hMG and FSH, increase your chances of becoming pregnant with multiples. For couples eager to have a baby, having more than one may sound even better (and in a study several years ago, the vast majority of infertility patients surveyed expressed a desire for twins, with half even liking the sound of triplets!). But it’s not ideal. Your pregnancy will be more complicated, you’ll be much more likely to deliver early, and the babies, as a result of their prematurity, may face days, weeks, even months in neonatal intensive care. Then, they’re more likely to have developmental disabilities.
INTRAUTERINE INSEMINATION (IUI) Sometimes fertility drugs are used with an in-office procedure to achieve pregnancy. In this, your husband produces a semen sample (by masturbation) and the doctor treats and inserts the sample directly into your uterus. If your husband also has fertility problems or tests have shown “penetration” problems (his sperm fail to penetrate your egg), the doctor can mix the sample with a variety of substances to help.
How long should you try IUI? Like Clomid, IUI usually works quickly if it’s going to work, says Dr. Silber. “If you haven’t conceived in several cycles, it’s time to move on,” he believes. Other specialists may suggest trying for six months or even a year.
What you need to think about: IUI isn’t cheap, costing anywhere from an estimated $1,400 to $4,000 a month. Unless there’s reason to believe that sperm getting into the uterus is your problem, you might want to cut your losses sooner. Moreover, each insemination cycle exposes you to the potential risks of fertility drugs. By going quickly or even directly to high-tech methods, you limit those risks.
HIGH-TECH HELP These are the superstars of infertility treatment, the procedures that have made pregnancy possible for couples who, not long ago, had no chances whatever—women whose tubes are completely blocked, for example, or men who produce no sperm at all. Basically, the treatments all start the same way: A woman takes a series of different drugs to stimulate ovulation (and to produce multiple eggs). Then, while she’s sedated, the doctor retrieves the eggs from the ovary.
Everything that follows egg retrieval—where fertilization occurs, how it’s achieved, and at what point the fertilized eggs are transferred back to the woman’s body—is a variation on a theme.
IN VITRO FERTILIZATION With IVF, the retrieved eggs are placed in a glass (petri) dish, where they mix with sperm provided by your husband. After two days, the fertilized eggs (now known as embryos) are transferred back to your uterus. Who should consider it? IVF was developed for women with blocked (or missing) fallopian tubes, and it’s still the procedure of choice for such women. But it’s also used for other problems, including unexplained infertility.
GAMETE INTRAFALLOPIAN TRANSFER In GIFT, a woman’s eggs are retrieved from the ovary, mixed with sperm, then immediately placed in her fallopian tube, where fertilization can take place as it does naturally. Who should consider it? Women who have at least one normal tube and whose husbands don’t have significant fertility problems.
ZYGOTE INTRAFALLOPIAN TRANSFER You could think of ZIFT as IVF meets GIFT—fertilization takes place in a petri dish, but the fertilized eggs are transferred (before they’ve become two-celled embryos) into the fallopian tube. Who should consider it? ZIFT was developed for cases where the woman has at least one normal tube and her husband has fertility problems.
INTRACYTOPLASMIC SPERM INJECTION ICSI is a truly stunning technique, where a single sperm is injected into an egg. The process then continues as with IVF. Who should consider it? Couples where the problem is male-factor infertility.
When one of Lisa Daly’s closest friends asked Lisa to hold her newborn son at the baby’s bris (the Jewish rite of circumcision), Lisa initially demurred. “It’s good luck,” her friend insisted. “It means you’ll have your baby soon.” Could that be what would work? Lisa, a registered nurse who specializes in monitoring high-risk pregnancies, and her husband, Ira, now a social studies teacher, had been trying to have a baby for five years. The Queens, New York, couple had undergone test after test, and everything had come back normal. They’d had surgery (a laparoscopy for her, repair of a varicose vein on his testicle for him). Still no pregnancy. Four attempts at intrauterine inseminations, with Clomid to boost ovulation, also failed. Even more heartbreaking, Lisa became pregnant once on her own, and once with Clomid, but miscarried both times. “I just lost it after the second one,” she admits. And then, a month later, only two weeks after holding her friend’s baby, Lisa started another cycle of Clomid and on Rosh Hashanah, the Jewish holy day of renewal, conceived her own son. Jacob Samuel Daly was born on May 27,1997.
CHOOSING A HIGH-TECH CENTER If you didn’t like high-school math, you’re going to have a tough time decoding the numbers that fertility centers tout as the basis of their success rates. But it’s more than worth the effort: IVF and its relatives are physically and emotionally demanding procedures, not to mention extremely expensive. Why use up your few chances to get pregnant at a center that isn’t experienced in your problem or that hasn’t had much success generally?
Fortunately, you have help: The Assisted Reproductive Technology Success Rates, a compendium of results from 300 or so clinics that are members of the Society for Assisted Reproductive Technology (SART). You can order copies by phone (888- 299-1585) or click on to the World Wide Web (Actually, it will take lots of clicks: The directory prints Out in three parts, 150 pages each.) And note: As of this printing, the directory currently available is based on 1995 records; the 1996 edition is expected to be available by year’s end. Also, starting with the 1996 directory, centers will be audited (on a random basis) as part of a government crackdown on misleading claims and practices at fertility clinics.
How do you interpret the numbers each center presents? Unscrupulous practitioners would probably like you to focus on one figure only: The number of live births achieved after embryos have been transferred to the mother’s womb. Why not? By definition, that has to be the highest figure, since it would eliminate from consideration all those cycles that had to be canceled at earlier points in the process because things hadn’t gone well—the woman had failed to produce enough good eggs, for example, or the eggs had failed to fertilize.
So the figure that’s generally most meaningful is the one that’s most comprehensive: Number of live births per cycles initiated, a figure that’s popularly called the “take-home baby rate.” But even that number isn’t as revealing as it sounds. Smaller, local centers, for example, may treat couples from the area. If the woman becomes pregnant, fine. If she doesn’t, though, she may move on to a larger clinic, which handles more difficult cases, explains Zev Rosenwaks, M.D., director of the Center for Reproductive Medicine and Infertility at New York Hospital-Cornell Medical Center in New York. The smaller center ends up with a high success rate—but all that reflects is the fact that the clinic’s largely treating couples who get pregnant more easily.
Other more insidious practices can be at work too. Centers have a great stake in publishing high success rates: They could, therefore, be bumping up couples with “easier” cases to the top of a waiting list, in hopes their higher odds will raise the center’s overall success rates. Or centers could be rejecting couples with severe problems or assigning such couples to a “research group,” so their numbers will be kept out of the overall rates. Conversely, centers whose figures seem on the low side may be more accepting of such difficult cases.
But if you can’t totally rely on the numbers, what can you look at?
EXPERIENCE “Centers where thousands of IVF cycles have been performed and many hundreds or thousands of women have become pregnant almost surely have mastered IVF,” says Joseph D. Schulman, M.D., director of the Genetics & IVF Institute in Fairfax, Virginia. And look for experience in your particular problem, advises Dr. Kearney.
NITTY-GRITTY NUMBERS Knowing certain specifics can signal whether a center is top-notch. Find out what percent of cycles a center cancels, advises Dr. Silber. “If the cancellation rate’s higher than 15 to 20 percent in women under 39, that’s a red flag,” he warns. Similarly, if a center is doing ICSI, embryos should be placed back in the womb successfully nearly all the time. “Failure should occur less than 2 percent of the time,” says Dr. Silber, “and only in patients with few or poor eggs.
COMPLICATION RATES High numbers of complications signal that a center may not be paying close enough attention. You could ask specifically about ovarian hyperstimulation risk, suggests Dr. Rosenwaks. “With careful monitoring, a center’s rate should be exceedingly low, less than 1 percent.”
INNOVATION You may not need to take advantage of any “firsts” a center has achieved, but being on the cutting edge of medical advances almost always implies a high degree of skill and knowledge, says Dr. Schulman.
QUESTIONS YOU WISH YOU DIDN’T HAVE TO THINK ABOUT It’s hard enough to realize that you’re not going to be able to conceive the “regular” way. On top of that, couples turning to high-tech procedures may have to grapple with difficult issues.
ARE HIGH-TECH BABIES HEALTHY? Generally, IVF babies are no more likely to suffer birth defects or other abnormalities, studies show. But male babies conceived through ICSI do have a higher risk of certain genetic defects. The reason: Men who have extreme infertility problems (very low sperm counts or no sperm at all) may have an inherited defect on their Y-chromosome, which they in turn may pass to their sons.
TOO MANY BABIES? In 1995, 28 percent of all assisted-reproductive technology births were twins, triplets, or higher- order births, according to the SART figures. You can avoid the risk of multiple births by limiting the number of embryos that are transferred back to the mother. But then you also cut the chances of success. Is there a happy medium, so to speak? Going beyond mere numbers, some specialists believe that checking the quality of embryos might be the ticket. Last spring, for example, the Northwest Center for Infertility and Reproductive Endocrinology in Margate, Florida, reported that they’d found the best “formula” for maximizing pregnancy rates while limiting higher-order (triplets or more) multiple conceptions:
For women 35 or younger, transfer up to four poor-quality, two fair-quality, or two good-quality embryos. For women 36 to 39, four poor-quality, three fair-quality, or two good-quality embryos. For women 40 and older, transfer five embryos, regardless of quality (any lower, the chances of success are too low).
WHAT ABOUT MULTIFETAL REDUCTION? One way around the problem of multiple births is to transfer a larger number of embryos, then “reduce” the number early in pregnancy (by injecting one or more fetuses with a solution that causes them to die). Aside from the painful emotional issues reduction raises, it is not a panacea: While it does cut your risks, in a study comparing “reduced” twins (from quadruplets) with twins that started out that way, the reduced twins averaged lower weights at birth and were more likely to be delivered early, possibly because of complications from the reduction procedure itself or possibly because of problems related to the implantation of a larger number of fetuses to begin with.
HOW LONG SHOULD YOU TRY? IVF is not like rolling dice, Dr. Kearney explains, where the more rolls, the greater your odds of success. Rather, couples with the fewest problems are more likely to get pregnant ”on an earlier throw”; those who are older or who have more medical problems are less likely. Nor, obviously, do such couples’ chances improve with time.
Finances aside (though with IVF averaging $8,000 to $10,000 per cycle, few couples can put finances aside), the latest numbers suggest that it’s worth trying at least three cycles. A just-released SART study found that success rates remain almost equal for the first two cycles of IVF, and then decline only modestly. After more than four cycles, however, pregnancy rates drop significantly. At that point, couples may want to explore other technologies (such as using donor eggs) or turn their energies to other ways of creating a family or having children in their lives.
Toni Gerber Hope is Redbook’s deputy editor. (Additional reporting by Andrea Bauman and Susan V Seligson.)