PGD - Pre-Implantation Genetic Diagnosis MVR - Microscopic Vasectomy Reversal ART Pregnancy Rates Sheet IVF - In Vitro Fertilization ICSI - Intra Cytoplasmic Sperm Injection Tubal Ligation Reversal Vasectomy Reversal vs. Sperm Injection: Dr. Silber’s Analysis Sperm, Embryo, and Ovarian Tissue Freezing and Storage Understanding Infertility Treatment Statistics Video:  Dr. Silber explains Assisted Reproductive Technology "How To Get Pregnant" - Dr. Silber's book "What’s New in Infertility" - Commentary by Dr. Silber Sperm Aspiration for ICSI Blastocyst Culture Video and Audio Library GIFT - Gamete Intra Fallopian Transfer Video:  Dr. Silber explains Microscopic Vasectomy Reversal Bibliography of Dr. Silber Biography of Dr. Silber Radio:  The biological clock discussed with Joan Hamburg TV:  Ovarian tissue transplantation on Montel Williams Preserving Your Fertility TV:  Antral Follicle Count (egg counting) TV:  Freezing the Biological Clock TV:  How to Find Out Where You Are On Your Biological Clock TV:  Dr. Silber Honors His Early Teacher on NBC News Today Show Dr. Silber explains egg and ovary banking to preserve fertility Whole Ovary Transplant Between Non-identical Sisters - Channel 11 St. Louis News Video Clip Whole Ovary Transplant Between Non-identical Sisters - Fox News St. Louis Video Clip Mini-IVF - Fox News St. Louis Video Clip
The Infertility Center of St. Louis

Welcome to the Infertility Center of St. Louis

To get feedback from patients who have undergone treatment at our Center, visit our Patient Comments page.

If you have any questions, you may call us at  (314) 576-1400.

Over the last 35 years, Sherman J. Silber, M.D., has pioneered most of the “miracle” infertility treatments now accepted around the world for male as well as female infertility. These breakthroughs include microscopic vasectomy reversal, tubal ligation reversal, ICSI (intra-cytoplasmic sperm injection), male infertility and improving success rates with IVF (in vitro fertilization) while reducing IVF costs and eliminating complications. Other areas include: egg freezing to preserve fertility, ovary transplantation and preserving fertility in cancer patients.

Learn more about Dr. Silber  

Dr. Sherman J. Silber, M.D.

We intend for this site to provide you with solid, extensive information on the latest in infertility, and to provide some information about our center. If you have any questions or would like even more information, please feel free to contact us.

Discovery Health Channel Documentary“Infertile couples from all over the world come to St. Louis, Missouri, to chase their dream, because Dr. Sherman Silber and his team are simply the best there is.” – Discovery Health Channel Documentary

Dr. Silber on Today Show“Dr. Silber performed IVF live on The Today Show. Watch the videos from the start process all the way to the ultra sound.” –Watch Dr. Silber with Happy Couple

Dr. Silber on GMA“Dr. Silber was featured on Good Morning America to talk about egg and ovary freezing to preserve fertility.” –Watch Dr. Silber on Good Morning America

Dr. Silber in Glamour Magazine“Could having a baby whenever you want really be simple? Dr. Silber discusses ovary freezing in Glamour Magazine.” –Read the Glamour Article with Dr. Silber Here

Cover of Dr. Sherman J. Silber’s book How to Get Pregnant

In 2007, Dr. Silber published a completely revised and updated version of his classic book, How to Get Pregnant, which lays out in simple, clear terms the basic information that will help infertile couples learn how they can have a healthy, happy baby, and help younger women preserve their fertility.

News Video of freezing the biological clock; the new techniques for preserving a woman's fertility indefinitely

News Video of freezing the biological clock; the new techniques for preserving a woman's fertility indefinitely.

Cancer patient Amy Tucker becomes pregnant after her frozen ovarian tissue is transplanted - Fox Channel 2 St. Louis

Cancer patient Amy Tucker becomes pregnant after her frozen ovarian tissue is transplanted by Dr. Silber- Fox Channel 2 St. Louis

St. Louis doctor helping women preserve chance at motherhood at no fees altruistically until the day when insurance will pay

St. Louis doctor helping women preserve chance at motherhood at no fees altruistically until the day when insurance will pay

  Dr. Silber Featured on 60 Minutes

Dr. Silber Featured on 60 Minutes

Listen to Dr. Sherman Silber on Joan Hamburg on WOR New York

Listen to Dr. Sherman Silber and Joan Hamburg discuss the remarkable infertility treatment meeting that recently took place in Hong Kong. WOR New York, February 28, 2013. (9:26 min)

Listen to Dr. Sherman Silber on KMOX Discussing Mini-IVF and Egg Freezing

Listen to Dr. Sherman Silber on KMOX Discussing Mini-IVF and Egg Freezing, September 16, 2012. (9:47 min)

Dr. Silber explains infertility treatments in depth in these videos and audio files, optimized for all connection speeds:

Assisted Reproductive Technology (ART) Video

Assisted Reproductive Technology (ART)

  Dr. Silber explains Microscopic Vasectomy Reversal (MVR): What works, what doesn't work, and why

Dr. Silber explains Microscopic Vasectomy Reversal (MVR): What works, what doesn't work, and why

Ovary cryopreservation and transplantation for fertility preservation

Dr. Silber Performs First Ever Ovary Transplant in China. Read More

Listen to Dr. Silber on Health and Wellness with Monica Adams

Listen to Dr. Silber on Health and Wellness with Monica Adams discussing egg freezing, male infertility, and mini-IVF on KMOX in St. Louis. January 29, 2012. (9:26 min)

What is ovary freezing for fertility preservation?

What is ovary freezing for fertility preservation?

  Why is Mini-IVF a Good Treatment for Older Women?

Why is Mini-IVF a Good Treatment for Older Women?

Listen to Dr. Silber and Joan Hamburg discuss the infertility epidemic on WOR Radio in New York

Listen to Dr. Silber and Joan Hamburg discuss the infertility epidemic on WOR Radio in New York. October 10, 2007. (24:29 min)

Listen to Dr. Silber discuss the biological clock, preserving your fertility and egg freezing on the KMOX Health and Fitness Show with Monica Adams

Listen to Dr. Silber discuss the biological clock, preserving your fertility and egg freezing on the KMOX Health and Fitness Show with Monica Adams. March 2, 2008. (20:58 min)

"Fertility: stop all the clocks" from The London Daily Telegraph Sunday Magazine

"Fertility: stop all the clocks" from The London Daily Telegraph Sunday Magazine

ABC News awards Dr. Silber "top ten" medical achievement of 2008

ABC News awards Dr. Silber "top ten" medical achievement of 2008

Ovary cryopreservation and transplantation for fertility preservation

Ovary cryopreservation and transplantation for fertility preservation. Molecular Human Reproduction, Vol.18, No.2, 2012

LIVESTRONG Quarterly magazine article, Summer/Fall 2011

"Survivors Reach New Fertile Ground" LIVESTRONG Quarterly magazine, Summer/Fall 2011. Read More

Vasectomy Reversal and Tubal Ligation Reversal:

Microscopic vasectomy reversal allows men who have had a vasectomy to become fertile again. Tubal ligation reversal does the same for previously sterilized women. Vasectomy reversal is performed under a microscope with very high magnification, using delicate instruments and suture that Dr. Silber designed specifically for this surgery. Dr. Silber re-operates on many men who have had unsuccessful vasectomy reversals elsewhere. Dr. Silber was the first in the US to perform microsurgical tubal ligation reversal, and was the first in the world to develop microsurgical vasectomy reversal. He has a success rate over 98% and has performed over 8,000 procedures, dwarfing all other centers in the world.

Watch a technical video about Microscopic Vasectomy Reversal

Vasectomy reversal technical video

  Dr. Silber explains Microscopic Vasectomy Reversal (MVR): What works, what doesn't work, and why

Dr. Silber explains Microscopic Vasectomy Reversal (MVR): What works, what doesn't work, and why

IVF and ICSI:

In vitro fertilization (IVF) means that fertilization takes place outside the body, in a small glass dish, and the fertilized eggs, i.e., embryos, are then placed directly into the uterus. IVF was originally used in cases where the fallopian tubes are damaged preventing natural pregnancy, but now it is successful for virtually all types of infertility. Intra-cytoplasmic sperm injection (ICSI) is recommended for fertilization to make sure the sperm (even poor quality sperm) fertilizes the egg properly. In ICSI, the eggs and the sperm are fertilized in the laboratory, by direct injection of a single sperm into each egg. The resulting embryos are then simply placed into the uterus with no surgery, just as with IVF. Dr. Silber and colleagues in Brussels were the original developers of intra-cytoplasmic sperm injection for the severest cases of male infertility, even azoospermia. Dr. Silber and Japanese collaborators have recently developed a new "mini-IVF" technique that saves money, eliminates complications of IVF, and is useful for older women and women with low ovarian reserve.

Watch a news video about ICSI

ICSI discussed on ABC World News Tonight

  Watch a technical video about ICSI ICSI technical video

Egg and Ovary Banking to Preserve Fertility:

There are now techniques to literally freeze your biological clock [video] and preserve your fertility so that you can have children later, when you are older and ready to have children. Egg, ovarian tissue, embryo, and sperm can all be preserved indefinitely, and furthermore we have perfected our freeze/thaw procedures to achieve success rates which are just as high as with "fresh" eggs. We even have the ability now to determine precisely where you are on your biological clock [video], so that you will know exactly how long your fertility can be expected to last. Egg and ovary freezing are remarkable for preserving fertility in young cancer patients who otherwise would become sterile as a result of their curative chemotherapy and radiation.

Egg and Ovary Banking to Preserve Fertility Video

Dr. Silber discusses Egg and Ovary Banking to Preserve Fertility

Fox 2 News video on Antral Follicle Count

Fox 2 News video on Antral Follicle Count

News video on Antral Follicle Count

Dr. Silber explains Antral Follicle Count on New York network TV.

Watch a news video about Freezing Your Biological Clock

Channel 11 News video on Freezing Your Biological Clock

Watch a video showing the Vitrification Process

Video Showing the Vitrification Process

Read The Wall Street Journal article about Ovary Tissue Freezing

New Way to Extend Fertility: Freeze Ovary Tissue Wall Street Journal; April 26, 2007

Ovary Transplantation:

First with identical twins, now with non-identical sisters. Using the same technique to freeze the ovary before cancer treatment, we can hold your biological clock so you can have children at a later time. Click the links below to learn more about ovary transplantation:

Watch a technical video about an Ovarian Tissue Transplant

Ovarian Tissue Transplant technical video

Update: Ovary Transplant Between Identical Sisters - Channel 11 St. Louis News Video Clip, April 30, 2007

Update: Ovary Transplant Between Identical Sisters - Channel 11 St. Louis News Video Clip, April 30, 2007

Trailer for BBC Documentary - “A Child Against All Odds: Gift of Life” Featuring Dr. Silber

Trailer for BBC Documentary - “A Child Against All Odds: Gift of Life” Featuring Dr. Silber

Leukemia patient cured by bone marrow transplant from her sister as a 4 year old, 25 years later receives ovary transplant from her sister to restore her lost fertility - Fox Channel 2 St. Louis

Leukemia patient cured by bone marrow transplant from her sister as a 4 year old, 25 years later receives ovary transplant from her sister to restore her lost fertility - Fox Channel 2 St. Louis.

Ovarian Tissue Transplant

Dr. Silber gives hope for young adults with cancer.

Vitrification of ovarian tissue to preserve fertility

Vitrification of ovarian tissue to preserve fertility.

Other procedures:

There are many other procedures that a couple battling with infertility can utilize. GIFT (Gamete Intra-Fallopian Transfer) is a reproductive technique for couples with religious objections to IVF whereby the husband's sperm and the wife's eggs are placed directly into her fallopian tube. Sperm aspiration is the technique for retrieving sperm directly from the testicles of men who have no sperm in the ejaculate. With advanced cryogenic technology, sperm, eggs, embryos, and ovarian tissue can be stored indefinitely to better ensure one's future fertility. This website contains detailed information on embryo freezing and sperm aspiration, as well as sperm and egg freezing, and uterine reconstructive surgery breakthroughs for adenomyosis.

Watch a technical video about Sperm Aspiration

Sperm aspiration technical video

  Watch a news video about Ovarian Tissue Freezing

Ovarian tissue freezing in the news

 
Watch a news video about Freezing Your Biological Clock

“Freezing Your Biological Clock” in the news

  Post-Op interview with 30 year old adenomyosis patient cured by Osada surgical procedure in St. Louis.

Post-Op interview with 30 year old adenomyosis patient cured by Osada surgical procedure in St. Louis.


The Infertility Center of St. Louis also offers pre-implantation genetic diagnosis (PGD) of embryos. This reduces the risk for miscarriages and multiple pregnancies, and provides screening for birth defects such as cystic fibrosis, muscular dystrophy, Tay-Sachs, and Down's syndrome, etc.

Watch a news video about Pre-Implantation Genetic Diagnosis (PGD)

PGD in the news

     

Other information:

Dr. Silber also answers some common questions about infertility in our Frequently Asked Questions section, and in transcripts from his guest appearances in an online chat at TalkCity.com and an online chat at Mom.com.

In the News focuses on important developments in the science of infertility treatment, with articles of general interest and a selection of some of Dr. Silber's scientific research papers. Also take a look at our selection of online video and audio (Media Library), optimized for downloading. Dr. Sherman Silber's detailed book, completely revised and updated in 2007, is summarized in the How to Get Pregnant section, as is a complete bibliography, for those who wish to study the field more deeply. About Dr. Silber gives you a closer look at the biography of this renowned pioneer in microsurgery and infertility.

A Special Message From Dr. Silber About Your Biological Clock and Preserving Your Fertility


Fertility Road magazine article, March/April 2011

"America is leaps and bounds ahead of the UK when it comes to fertility treatment, particularly in the field of Ovarian Tissue Freezing…" Fertility Road magazine, March/April 2011. Read More

Fertility Road magazine article, May/June 2011

"For women who are told IVF isn't an option, mini-IVF could be a more successful path to parenthood…" Fertility Road magazine, May/June 2011. Read More

Patients relate their experiences with The Infertility Center of St. Louis

Two of Dr. Silber's patients relate their experiences receiving care at the Infertility Center of St. Louis.

  Click here to see more videos from the Infertility Center St. Louis Media Library

Click here to see more videos from the Infertility Center St. Louis Media Library.