The reliability of antral follicle count is completely independent of the menstrual cycle. Unlike hormone evaluations, the ultrasound evaluation of antral follicle count can be used on any day of the menstrual cycle to show those follicles that have left the resting state and have reached the antral size. This is a daily event that occurs independently of all the other monthly variations in the menstrual cycle.
Antral follicle count can, of course, be used for counseling infertile women about to undergo IVF so that they will know what their chances are for a successful result. However, it is also extremely useful for all women who are thinking about getting pregnant either sooner or later, and who need to know if it is risky for them to put this decision off. It is even possible to predict at what age menopause will occur. Fertile women who have an antral follicle count of twenty to forty, regardless of age, can anticipate becoming infertile within ten to fifteen years and will likely reach menopause about ten years later. An otherwise fertile woman whose antral follicle count is only ten is likely to become infertile very soon, and to have menopause within about thirteen years. Women who have antral follicle counts of less than five are very unlikely to be able to get pregnant with or without infertility treatment, and they are likely to have menopause begin sometime within the next seven to eight years. Of course, these are average and median figures, and cannot predict exactly for each individual patient. But it can be concluded that even younger women with antral follicle counts of less than ten (total from both ovaries) have no time to waste if they want to have children.
Thus, transvaginal ultrasound, which should be a simple and readily available tool in most gynecologists’ offices and certainly in any radiology imaging center, as well as blood AMH levels, can provide an accurate and reproducible measurement of the total number of antral follicles throughout the menstrual cycle, which is indicative of the woman’s ovarian reserve and her reproductive future.