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The ice man: Dr. Sherman Silber at the Infertility Center of St. Louis, Missouri, where he has developed the technique of ovarian tissue removal, freezing and re-transplanting.
Dr. Sherman Silber at The Infertility Center of St. Louis, Missouri, where he has developed the technique of ovarian tissue removal, freezing, and re-transplanting, as well as the ICSI and mini-IVF procedures, and microsurgery for vasectomy reversal and sperm retrieval in men who supposedly have no sperm.

The Infertility Center of St. Louis

We are a leading-edge infertility center. This website will address many of your infertility questions. You should feel free to call the office for more details. You may also wish to read my book, “How To Get Pregnant” which is available in libraries and major bookstores.

We specialize in treating very difficult cases of infertility, e.g. where there has been previous failure to fertilize, failure to achieve pregnancy in previous efforts, or failed attempts at vasectomy reversal, etc. We are also happy to treat simpler infertility cases if so requested. Patients fly to our center in St. Louis daily from all over the world and we are quite accustomed to making them feel comfortable here.

Our approach is to avoid needless and often expensive conventional testing, as well as outmoded treatments that unfortunately are often used for years until the couple is finally emotionally and financially drained. On the contrary, our policy is to recommend the most effective technology that is most likely to get the patient pregnant the soonest.

Many couples waste years going through many thousands of dollars worth of unnecessary tests that have little scientific validity and do not add any benefit to their treatment plan. They may undergo useless surgery (such as varicocelectomy on the man, or laser vaporization of endometriosis in the woman) that costs time and money, yet has no scientifically-validated benefit. This plethora of inappropriate care, and often frank incompetence, is fostered by commercialism that has unfortunately aggravated the modern infertility epidemic. You, therefore, must be a fully informed and questioning consumer to benefit from the truly exciting modern technology that now allows most infertile couples to fulfill their dreams and have a baby.


“Infertile couples from all over the world come to St. Louis, Missouri, to chase their dream, because Dr. Sherman Silber and his team are simply the best there is.” – Discovery Health Channel Documentary

About Dr. Silber

Dr. Sherman Silber Office PicDr. Sherman Silber, a renowned pioneer in microsurgery and infertility, is considered one of the world’s leading authorities in the field of infertility. This includes IVF, mini-IVF, sperm retrieval, ICSI, vasectomy reversal, male infertility, tubal ligation reversal, egg and embryo freezing, ovary transplantation and the reproductive biological clock.

For over 43 years Dr. Silber has originally developed all of the most popular fertility treatments used around the world today.

He performed the world’s first microsurgical vasectomy reversal, as well as the first testicle transplant, in the 1970s and now in the current century, the world’s first ovary transplant. He was the first to develop the TESE, MESA, and ICSI techniques for retrieving testicular and epididymal sperm in azoospermic men and injecting into the wife’s eggs. He headed the clinical MIT team that first mapped and sequenced the Y chromosome in infertile men and discovered the now-famous DAZ gene for male fertility. He was the first to bring and popularize the completely “game-changing” vitrification (i.e. modern, flawless, freezing) technique to the United States from Japan. His research includes also the study of reproduction and fertility in zoo animals and endangered species. Most recently he has perfected the preservation of fertility for cancer patients with ovarian freezing and transplantation and thereby figured out how to extend the reproductive biological clock of women. He has helped pioneer minimal ovarian stimulation to reduce IVF costs and eliminate complications while maintaining the very highest success rates, even in older women. He has even recently answered the age-old question of why the dinosaurs went extinct by extending his research on male infertility and the Y chromosome, discovering that the change in earth temperature 65,000,000 years ago led to the birth of a skewed male/female sex ratio. Doctor operatingHis most current research project is making sperm and eggs from skin biopsies.

Dr. Silber has treated many thousands of infertile couples who travel to St. Louis daily from all over the world. His patients come from every state in the U.S.A., all over Europe, South America, the Middle East, Asia, and Africa. His patients include doctors, teachers, rock stars, secretaries, politicians, astronauts, movie stars, scientists, truck drivers, lawyers, migrant fruit pickers, CEO’s, princes and kings.

He is the author of five medical textbooks, five best-selling books for the layman and more than 250 scientific papers on human infertility and reproduction. “How to Get Pregnant”, published by Little, Brown and Company, has been a major bestseller in the United States, and Dr. Silber’s books have been published in English, Spanish, German, Chinese, and Russian. He has appeared many times on the Today Show, the Donahue Show, Gary Collins, Peter Jennings ABC Nightly News, Oprah, Charlie Rose, and Ted Koppel Nightline. He has been a consultant numerous times on the Joan Rivers Show and ABC News, Good Morning America, and has been a regular contributor many times on CNN, KMOX, WOR, and NPR radio. Discovery Channel has aired many documentaries on his work.


Dr. Silber went to medical school at the University of Michigan, did post-graduate training at Stanford University, the University of Melbourne in Australia, and then again at the University of Michigan. From 1967 to 1969, he provided medical care via the U. S. Public Health Service to Eskimos, Indians, and Aleuts. Then he taught at the University of Melbourne Medical School in Australia, and later at the University of California Medical School in San Francisco. He is a scientific collaborator at MIT in Cambridge, Massachusetts, at the Kato Clinic in Tokyo, and is a full professor at the University of Amsterdam, The University of Michigan and at Sun Yat Sen University Medical School in China. His major clinical medical practice however is at St. Luke’s Hospital in St. Louis, Missouri.

2006-07-16_TodayShowHe always gives credit for his amazing surgical dexterity to the training he received during medical school from an uneducated but brilliant Black janitor who washed instruments at the animal lab at the University of Michigan. He honored his incredible surgical teacher on the NBC News Today Show in 2006.


Learn more about:



“Survivors Reach New Fertile Ground” LIVESTRONG Quarterly magazine, Summer/Fall 2011. Read More


“America is leaps and bounds ahead of the UK when it comes to fertility treatment, particularly in the field of Ovarian Tissue Freezing…” Fertility Roadmagazine, March/April 2011.Read More


Dr. Silber Performs First Ever Ovary Transplant in China.Read More


High Doses of Hormones Faulted in Fertility Care – The New York Times
Read More


Cross-cultural Fertilization: Dr. Sherman Silber Takes His Reproductive Technology to China – St. Louis Magazine; August 2012
Read More

See also:

To get feedback from patients who have undergone treatment at our Center, click here to go to the Patient Comments page.

If you have any questions, you may call us at  (314) 576-1400