[St. Louis, Missouri] — [April 15, 2026] — The Infertility Center of St. Louis (IFC) announced today the successful second pregnancy in a patient with Turner syndrome following an ovarian allotransplantation. Turner syndrome is a rare chromosomal disorder that impacts young females and often results in a decreased ability to become pregnant as adults. This remarkable case opens the ability for individuals with few or no eggs to have children naturally.
“This is a profound moment for patients with the most severe forms of infertility seeking to become parents,” said Dr. Sherman Silber, Director of the Infertility Center of St. Louis. “This patient’s second pregnancy marks a meaningful step in validating the real-world impact of the procedures we have innovated for preserving fertility and achieving pregnancy in the most challenging cases.”
Fertility can be preserved for young women by freezing their ovarian cortical tissue with the plan to transplant it back later. In most cases, the patient’s own tissue is used. In this case, the tissue was donated by the patient’s sister, with one‑third implanted into the patient, who did not have functioning ovaries, and the remaining two‑thirds cryopreserved. The procedure has resulted in two natural pregnancies for the patient – first in 2023 and again in 2026.
“This patient’s journey reflects the intersection of compassionate care and rigorous science,” Dr. Silber said. “It shows what is possible when we combine innovation, multidisciplinary expertise, and individualized treatment planning. Behind every scientific milestone is a patient’s hope. This second pregnancy is a powerful reminder of why fertility preservation matters, and why continued innovation in the field can expand possibilities for patients who once had very limited options.”
This successful case underscores emerging evidence supporting advanced interventions as viable options for patients facing infertility due to the most serious medical conditions, age-related ovarian decline, or prior gonadotoxic treatment.
About IFC
Infertility Center of St. Louis is dedicated to providing personalized, evidence-based fertility treatment and fertility preservation. It specializes in treating the most difficult cases of infertility, including prior unsuccessful attempts such as IVF, hormone therapy, or surgical procedures, including tubal reversal and vasectomy reversal.

