PGD - Pre-Implantation Genetic Diagnosis MVR - Microscopic Vasectomy Reversal ART Pregnancy Rates Sheet IVF - In Vitro Fertilization ICSI - Intra Cytoplasmic Sperm Injection Tubal Ligation Reversal Vasectomy Reversal vs. Sperm Injection: Dr. Silber’s Analysis Sperm, Embryo, and Ovarian Tissue Freezing and Storage Understanding Infertility Treatment Statistics Video:  Dr. Silber explains Assisted Reproductive Technology "How To Get Pregnant" - Dr. Silber's book "What’s New in Infertility" - Commentary by Dr. Silber Sperm Aspiration for ICSI Blastocyst Culture Video and Audio Library GIFT - Gamete Intra Fallopian Transfer Video:  Dr. Silber explains Microscopic Vasectomy Reversal Bibliography of Dr. Silber Biography of Dr. Silber Radio:  The biological clock discussed with Joan Hamburg TV:  Ovarian tissue transplantation on Montel Williams Preserving Your Fertility TV:  Antral Follicle Count (egg counting) TV:  Freezing the Biological Clock TV:  How to Find Out Where You Are On Your Biological Clock TV:  Dr. Silber Honors His Early Teacher on NBC News Today Show Dr. Silber explains egg and ovary banking to preserve fertility Whole Ovary Transplant Between Non-identical Sisters - Channel 11 St. Louis News Video Clip Whole Ovary Transplant Between Non-identical Sisters - Fox News St. Louis Video Clip Mini-IVF - Fox News St. Louis Video Clip
The Infertility Center of St. Louis

Preserving Your Fertility New technologies slow down the "biological clock"

To get feedback from patients who have undergone treatment at our Center, click here to go to the Patient Comments page.

If you have any questions, you may call us at  (314) 576-1400.

Egg and Ovary Banking to Preserve Fertility Video

Video of Dr. Silber discussing Egg and Ovary Banking to Preserve Fertility

What is ovary freezing for fertility preservation?

What is ovary freezing for fertility preservation?

Listen to Dr. Silber discuss the biological clock, preserving your fertility and egg freezing on the KMOX Health and Fitness Show with Monica Adams

Listen to Dr. Silber discuss the biological clock, preserving your fertility and egg freezing on the KMOX Health and Fitness Show with Monica Adams. March 2, 2008. (20:58 min)

Listen to Dr. Silber and Joan Hamburg discuss the infertility epidemic on WOR Radio in New York

Listen to Dr. Silber and Joan Hamburg discuss the infertility epidemic on WOR Radio in New York. October 10, 2007. (24:29 min)

"Fertility: stop all the clocks" from The London Daily Telegraph Sunday Magazine

"Fertility: stop all the clocks" from The London Daily Telegraph Sunday Magazine

Cancer patient Amy Tucker becomes pregnant after her frozen ovarian tissue is transplanted - Fox Channel 2 St. Louis

Cancer patient Amy Tucker becomes pregnant after her frozen ovarian tissue is transplanted by Dr. Silber- Fox Channel 2 St. Louis

What do Patients Think of Fertility Preservation?

What do Patients Think of Fertility Preservation?

Freezing the biological clock - Channel 11 News St. Louis

Freezing the biological clock; the new techniques for preserving a woman's fertility indefinitely - Channel 11 News St. Louis

Ovary cryopreservation and transplantation for fertility preservation

Ovary cryopreservation and transplantation for fertility preservation. Molecular Human Reproduction, Vol.18, No.2, 2012

Listen to Dr. Silber and Joan Hamburg discuss the infertility epidemic on WOR Radio in New York

Listen to Dr. Silber and Joan Hamburg discuss male infertility, mini-IVF, fertility preservation, and infertility trends on WOR Radio in New York. February 2, 2012. (12:57 min)

Ovary cryopreservation and transplantation for fertility preservation

Dr. Silber Performs First Ever Ovary Transplant in China. Read More

Cover story on The Riverfront Times: The Egg Man - Dr. Sherman Silber says he can extend a woman's fertility by decades. He just needs to freeze her eggs or even a piece of her ovarian tissue; October 4, 2007

Cover story on The Riverfront Times: The Egg Man - Dr. Sherman Silber says he can extend a woman's fertility by decades. He just needs to freeze her eggs or even a piece of her ovarian tissue; October 4, 2007

Multiple Sclerosis (MS) Patient, Dr. Silber's Blog, September 18, 2012

"Multiple Sclerosis (MS) Patient" Dr. Silber's Blog, September 18, 2012

Listen to Dr. Silber and Joan Hamburg discuss the infertility epidemic on WOR Radio in New York

Listen to Dr. Silber on KMOX Discussing Mini-IVF and Egg Freezing. September 16, 2012. (9:47 min)

St. Louis doctor helping women preserve chance at motherhood at no fees altruistically until the day when insurance will pay

St. Louis doctor helping women preserve chance at motherhood at no fees altruistically until the day when insurance will pay

  Dr. Silber Featured on 60 Minutes

Dr. Silber Featured on 60 Minutes

Listen to Dr. Sherman Silber on Joan Hamburg on WOR New York

Listen to Dr. Sherman Silber and Joan Hamburg discuss the remarkable infertility treatment meeting that recently took place in Hong Kong. WOR New York, February 28, 2013. (9:26 min)

Preserving Your Fertility

A woman is born with approximately two million eggs in her ovaries. By her teenage years, this number is reduced to about 400,000. She will subsequently lose about one thousand eggs each month, until eventually no eggs remain. At that point, she begins menopause. The pace of this inexorable loss of eggs as a woman gets older is not affected by birth control pills, pregnancies, nutritional supplements, healthy living, or youthful appearance.

The ticking of her ovarian biological clock, and not knowing where she is on that biological clock, is one of the biggest dilemmas every woman faces [see Channel 11 St. Louis TV news video].

Most women (98%) are fertile through their early twenties. Yet by their mid thirties, the infertility rate increases to almost 30%. This phenomenon, referred to as the “biological clock”, is a direct result of the limited egg supply with which each woman is born.

Where are you on your biological clock? Many of the methods currently used to determine a woman's fertility are incorrect, and can lead to useless (and costly) ‘treatments’. These ineffective fertility tests generally fail to address the major factor in the decline of a woman's fertility: the aging of her ovaries.

Assessing where you are on your particular biological clock has always been like peering into a black box.

Some women remain fertile well into their forties, while others lose their fertility in their early twenties. Some of us have to face unexpected disease (like cancer, the treatment of which, though it can save your life, threatens to wreck your chances to have children). We all simply have to face age, as we are pressured to put off pregnancy by unexpected turns of career and marriage. You have your life and your career, which in the modern world may mean putting off childbearing, but nonetheless you do want eventually to have children.

Fortunately, there are now three new technologies to address this dilemma. They are called Antral Follicle Count (AFC), Ovarian Tissue Freezing, and Egg Freezing.

Presently, there is a simple test to determine where you are on your biological clock: the Antral Follicle Count (AFC). (Ineffective old-fashioned tests are described here.)

Antral Follicle Count [see FOX St. Louis TV news video] is a precise technique of determining your ovarian reserve. Popularized in St. Louis by Dr. Silber, ultrasound is used to count the number of eggs left in your ovaries (more on Antral Follicle Count [see FOX New York TV news video]). We can thus calculate where you are on the biological clock (and even calculate the time remaining until menopause). This ultrasound test can be performed by any radiology center or gynecologist who is aware of what to look for (unfortunately, most still do not). Fortunately, the information needed to perform this test is not complicated, and can be easily described to your radiologist/ob-gyn by Dr. Silber's book, How to Get Pregnant, in the chapter, “Beating Your Biological Clock”.

Antral Follicle Count is a singularly empowering tool in your decisions about career, marriage, birth control, and when you need to start being concerned. It solves one half of the riddle of preserving your fertility: knowing how long it will last.

There are now safe, successful techniques to preserve a woman’s fertility indefinitely.

Recent advances in cryopreservation make it possible to preserve female fertility for any length of time. [see video] It’s well known that for some years we have been able to preserve fertilized eggs, or embryos; we can freeze them indefinitely, then thaw the embryos at a later date, and achieve high pregnancy rates in IVF [See Sperm, Egg, Embryo, and Ovarian Tissue Freezing]. It’s essentially a time-delayed IVF procedure, with a waiting period as long as you like, from when we retrieve and fertilize the egg, until we do the embryo implantation.

But for unmarried women, the trouble had previously been that this freezing process (although safe for embryos) destroyed unfertilized eggs, because eggs are so much more sensitive to freezing damage than embryos. If she did not have a husband yet and didn’t want anonymous donor sperm, the standard egg freezing procedures could do nothing for preserving her fertility… until now!

Ovarian Tissue Freezing and reimplantation, which Dr. Silber helped to pioneer, and egg vitrification pioneered in Japan, changed all that. An ovary could be (1) removed from cancer patients before radiation and chemotherapy, (2) frozen for some time, and then (3) returned to her body successfully after the cancer had been cured. The key realization was that all of the eggs in each ovary live only in the outermost layer of tissue, just 1 mm thick. The ready diffusibility of cryoprotectant into this thin layer, and the primordial immaturity of this storehouse of undeveloped eggs, allows ovarian tissue (and the eggs within it) to be frozen successfully. With the right microsurgical techniques, just this outer layer can be removed, frozen, and successfully grafted back on to the ovary at a later date, somewhat like a skin graft.

Fertility Road magazine article, March/April 2011

"America is leaps and bounds ahead of the UK when it comes to fertility treatment, particularly in the field of Ovarian Tissue Freezing…" Fertility Road magazine, March/April 2011. Read More

Vitrification of ovarian tissue to preserve fertility

Vitrification of ovarian tissue to preserve fertility.

This was a great success for female cancer patients [see technical video], and we realized that the same principles could be applied to preserve any woman’s fertility. She does not need to have found a partner yet, because the eggs can be preserved unfertilized. Furthermore, once the ovarian tissue layer is put back in her body, she can become pregnant by natural intercourse, without the need for additional IVF procedures.

A second option is to simply freeze her eggs with vitrification. Recently, the Infertility Center of St. Louis began partnering with the Kato Ladies Clinic in Tokyo, Japan, to bring these revolutionary egg vitrification [see video] techniques to the United States. With these procedures, even unfertilized eggs can be preserved indefinitely. We thus have two different approaches to beat the biological clock.

Some women may prefer egg freezing, because it does not involve a laparoscopy; only transvaginal ultrasound-guided needle aspiration. Still, it can require many aspirations plus preliminary medication to give them some assurance that they will have enough eggs frozen to insure them a high likelihood of future pregnancy. Other women will prefer ovarian biopsy because it involves no preliminary medication; only one brief outpatient procedure (and not multiple egg retrievals). Some women may prefer to do both just as an extra measure of assurance. Whichever strategy is chosen, a woman now has the option to breathe more easily, and not feel rushed into marriage or pregnancy before she is ready! Even those for whom egg donation is forbidden for religious reasons now have the option of ovarian tissue transplant [see technical video] or to read a detailed scientific paper on Ovarian Transplantation, Click Here [PDF File]. Also, you can watch News Coverage of an Ovarian Tissue Transplant [see video]

Research on the biological clock continues to go forward.

By studying and comparing the RNA expression of pairs of twins where the biological clock of one of the twins is shorter than that of the other, we hope that we will be able to determine the genomic regions where ovarian reserve, and hence the biological clock of women, is located. Since the biological clock is the main reason for the current worldwide infertility epidemic, this research may give us important genetic clues to the cause of this epidemic.

However, for right now, it is most important to realize, even as our scientific knowledge is still deepening, that clinically, we can already solve this problem for women, today. We simply need to preserve the fertility of young women by stopping their biological clock from ticking away, either by freezing their ovarian tissue or by freezing retrieved eggs.

Interview in 2011 with Amy Tucker whose ovary was frozen in 1997 as a young girl prior to undergoing sterilizing cancer treatment

Interview in 2011 with Amy Tucker whose ovary was frozen in 1997 as a young girl prior to undergoing sterilizing cancer treatment.

LIVESTRONG Quarterly magazine article, Summer/Fall 2011

"Survivors Reach New Fertile Ground" LIVESTRONG Quarterly magazine, Summer/Fall 2011. Read More

High Doses of Hormones Faulted in Fertility Care - The New York Times

High Doses of Hormones Faulted in Fertility Care - The New York Times
Read More

Cross-cultural Fertilization: Dr. Sherman Silber Takes His Reproductive Technology to China - St. Louis Magazine

Cross-cultural Fertilization: Dr. Sherman Silber Takes His Reproductive Technology to China - St. Louis Magazine; August 2012
Read More

See also:

Trailer for BBC Documentary - “A Child Against All Odds: Gift of Life” Featuring Dr. Silber

Trailer for BBC Documentary - “A Child Against All Odds: Gift of Life” Featuring Dr. Silber

Read The Wall Street Journal article about Ovary Tissue Freezing

New Way to Extend Fertility: Freeze Ovary Tissue Wall Street Journal; April 26, 2007

Treatment of Endometriosis with the Osada Procedure - Dr. Silber explains and demonstrates the Osada procedure and discusses the use of this procedure

Treatment of Endometriosis with the Osada Procedure - Dr. Silber explains and demonstrates the Osada procedure and discusses the use of this procedure.

Multiple Sclerosis (MS) patient, who is also a physician, chooses to preserve her fertility

Multiple Sclerosis (MS) patient, who is also a physician, chooses to preserve her fertility

Beating the Clock? Frozen Ovaries Make Headlines

Beating the Clock? Frozen Ovaries Make Headlines - The discovery offers hope for women undergoing reproductively-destructive therapy

23 year old with cancer (Hodgkin's Disease) chooses to freeze her ovaries to preserve her fertility

23 year old with cancer (Hodgkin's Disease) chooses to freeze her ovaries to preserve her fertility

Leukemia patient cured by bone marrow transplant from her sister as a 4 year old, 25 years later receives ovary transplant from her sister to restore her lost fertility - Fox Channel 2 St. Louis

Leukemia patient cured by bone marrow transplant from her sister as a 4 year old, 25 years later receives ovary transplant from her sister to restore her lost fertility - Fox Channel 2 St. Louis.

  Dr. Silber interviews a patient about to undergo ovary tissue freezing before undergoing sterilizing bone marrow transplant for aplastic anemia.

Dr. Silber interviews a patient about to undergo ovary tissue freezing before undergoing sterilizing bone marrow transplant for aplastic anemia.

Fertility preservation for Leukemia patients

Fertility preservation for Leukemia patients.

Listen to Dr. Silber on Health and Wellness with Monica Adams

Listen to Dr. Silber on Health and Wellness with Monica Adams discussing egg freezing, male infertility, and mini-IVF on KMOX in St. Louis. January 29, 2012. (9:26 min)

In danger of losing her only remaining ovary, very beautiful 24 year old talks about freezing her eggs

In danger of losing her only remaining ovary, very beautiful 24 year old talks about freezing her eggs.

  23 year old synovial sarcoma cancer patient talks about preserving her fertility.

23 year old synovial sarcoma cancer patient talks about preserving her fertility.

38 year old breast cancer patient who needs to start chemotherapy in a few days

38 year old breast cancer patient who needs to start chemotherapy in a few days.

What is ovary freezing for fertility preservation?

St. Louis doctor helping women preserve chance at motherhood at no fees altruistically until the day when insurance will pay

 

If you have any questions, you may call us at  (314) 576-1400.