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Infertile patients cannot afford to wait for treatment while their eggs get older.

Dr. Sherman Silber, Infertility Center of St. Louis, is offering video consultations for patients who need to plan now for their treatment while stay-at-home orders are in place. He is talking to and evaluating patients in their home to comply with social distancing measures.

Dr. Silber is discovering that patients actually prefer this method of telemedicine consultation over the conventional office visit. Patients have conveyed that “it is so much more convenient and less stressful” to have a telemedicine personal consultation than to take a day off from work to travel to the doctor’s office and sit with other nervous patients in the waiting room.

The COVID-19 pandemic is thus changing much of the way we will do things in the future, and for the better. “Our patients are surprisingly much happier with this approach. Of course, at some point we need to perform hands on treatment. But with this new manner of seeing patients, we can come to the right diagnosis and treatment plan for most patients more efficiently, quickly, and painlessly, with no loss of personal one-on-one communication.” This is a very welcome new era of telemedicine that has been forced on us by the current difficult times.

ICSI | Intracytoplasmic Sperm Injection

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blog-portrait-smDr. Silber explains that ICSI offspring are normal, and are no different from naturally conceived children – Read More


Audio: Dr. Silber and Joan Hamburg discuss how 20 years of studies clearly show ICSI babies are normal (WOR Radio in New York, April 26, 2012)


Will My Baby Be Normal?
An excerpt from How to Get Pregnant by Dr. Sherman Silber, published by Little, Brown and Company. (PDF, 800K)

ICSI (Intra Cytoplasmic Sperm Injection)

Micro-manipulation set up for ICSI

If there is a question of the sperm’s ability to fertilize the egg, due to either a low sperm count or poor quality of the sperm, that poses no problem whatsoever. Intra-Cytoplasmic Sperm Injection (ICSI) would be performed instead of regular In Vitro Fertilization (IVF).  In fact, we now use ICSI for all our IVF cycles. With ICSI, the eggs are retrieved the same as if you were doing conventional IVF. However, the eggs and the sperm are then fertilized in the laboratory, by direct injection of a single sperm into each egg. Three days later the resulting embryos are simply placed into your uterus with no surgery, just as with IVF. Extra embryos are frozen for later attempts at pregnancy.

The availability of this Intra-Cytoplasmic Sperm Injection, “ICSI” technique (which was originally developed and perfected by our institution in St. Louis and Brussels University) means that men whose sperm previously were too weak or too few to fertilize in vitro (IVF), now have no problem fertilizing their wife’s eggs.

The fertilization rate per egg using ICSI is over 90% now in our blank, the fertilization rate per infertile couple is over 99% if the wife has adequate eggs and the pregnancy rate per treatment cycle is over 90% per transfer is over 60%.  This is actually better than conventional I with normal sperm. This technique is very cost effective and will give you the same chance of getting pregnant as any couple with normal sperm. In fact, we now do only ICSI with all our IVF cycles because we get such a high fertilization rate, superior to just mixing sperm in with the eggs and hoping they will fertilize. Furthermore here is our history with ICSI, since we were the very first in the world to develop it.

How Does ICSI Work?


At first in Brussels, then in St. Louis, we showed the world how we can take a single, almost non-moving “dead” appearing sperm and inject it into a woman’s egg, getting in 1992 a normal embryo and a completely normal baby. So far over several million babies have been born with this technique from men who were other considered hopelessly sterile. The babies are completely normal physically, mentally, and genetically no matter how poor or miserable the sperm of the father. We are so experienced and efficient with ICSI that there are no added fees for us doing it. ICSI is just a routine part of IVF for us. The success of ICSI is very dependent on the right techniques, which we were the center to originally develop. It is easy unfortunately for labs that are in too big a hurry to damage the nuclear (“spindle”) of the egg. We can take a man who would otherwise have to resort to donor sperm and if we can find just a few weak sperm in his otherwise sterile appearing ejaculate, it is more than enough to micro-surgically inject these few sperm into his wife’s eggs, fertilize them normally and get her pregnant.

If there is absolutely no sperm in the ejaculate, we can perform a testicle biopsy, remove the few non-moving sperm that we find through a highly refined ultra micropipette, inject it into the wife’s egg and still get her pregnant. Even in testicles where allegedly there is no sperm production, we can usually (but not always) find a few sperm, which is enough for successful ICSI.

We were the IVF center that first developed all these ICSI related techniques and therefore we have the most experience in the world with it. If you have had a vasectomy reversed that failed it is no problem. We can just retrieve the sperm with no pain (believe it or not from your testes) and with ICSI and get the same high pregnancy rate.


Figure 1:
Immobilizing the sperm’s tail before picking it up.


Figure 2:
Injection of sperm into the egg.


Figure 3:
Fertilized egg demonstrating the two nuclei – one from the father, one from the mother.


See also:

Comparing Microscopic Vasectomy Reversal vs. Sperm Retrieval and ICSI – Dr. Silber’s conclusions

If you have any questions, you may call us at  (314) 576-1400.