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Infertile patients cannot afford to wait for treatment while their eggs get older.

Dr. Sherman Silber, Infertility Center of St. Louis, is offering video consultations for patients who need to plan now for their treatment while stay-at-home orders are in place. He is talking to and evaluating patients in their home to comply with social distancing measures.

Dr. Silber is discovering that patients actually prefer this method of telemedicine consultation over the conventional office visit. Patients have conveyed that “it is so much more convenient and less stressful” to have a telemedicine personal consultation than to take a day off from work to travel to the doctor’s office and sit with other nervous patients in the waiting room.

The COVID-19 pandemic is thus changing much of the way we will do things in the future, and for the better. “Our patients are surprisingly much happier with this approach. Of course, at some point we need to perform hands on treatment. But with this new manner of seeing patients, we can come to the right diagnosis and treatment plan for most patients more efficiently, quickly, and painlessly, with no loss of personal one-on-one communication.” This is a very welcome new era of telemedicine that has been forced on us by the current difficult times.

How the ICSI Outcome Is Impacted by Y Chromosome Deletions


Impact of Y Chromosome Deletions on ICSI Outcome

Study finds deletions in 13 per cent of azoospermia cases

IVF news, v8, n4, 1997

docivfpcA study of 125 azoospermic men treated by ICSI for infertility has confirmed that a moderate proportion of them (13 per cent) have deletions on the Y chromosome. The study was undertaken by Dr. Sherman Silber  at St. Luke’s Hospital in St. Louis, in collaboration with Dr. David Page and colleagues at Howard Hughes Medical Institute of the Massachusetts Institute of Technology. It was the latter group which first identified deletions on the Y chromosome of some men with sperm abnormalities–and which first raised concerns over inherited infertility in male factor ICSI cases.

The study reported by Dr. Silber at an ASRM session at ESHRE was undertaken in men with maturation arrest or Sertoli cell only conditions, 49 of whom were treated by testicular sperm extraction (TESE) and ICSI. There were an additional 28 cases of oligozoospermic men who underwent ICSI with ejaculated sperm. The aim of the study was to identify the extent of Y chromosome deletions and their impact.

Sixteen of the 125 azoospermic and two of the 28 oligozoospermic cases were found to have deletions of the DAZ (deleted in azoospermia) gene cluster. Similarly, eight of the 49 patients treated by TESE were found by Y DNA testing to be DAZ deleted.

Treatment outcomes from those who were and were not Y deleted suggests that the presence of Y deletions does not prevent the detection of sufficient sperm cells for ICSI–nor for the likelihood of pregnancy, for pregnancies occurred in those who were and were not Y deleted at a similar rate from both ejaculated and extracted sperm.

The embryo implantation rate was not significantly different for azoospermic (22 per cent), oligozoospermic (16 per cent), Y deleted (14 per cent) and Y intact (18 per cent) cases.

As a result of the study, Dr. Silber told an overcrowded meeting room that Y deletion appears to have no negative impact on the clinical results of ICSI. Similarly, DAZ deletions do not appear to preclude finding adequate sperm cells for TESE and ICSI.

However, Dr. Silber was quick to concede that DAZ expression on the Y chromosome is nothing like the whole story of genetic factors in male germ cell development. And indeed, when asked if such results were an indication for the genetic screening and counseling of all men thought suitable for ICSI, Dr. Silber answered ‘no’. The reason? That, if no more than 13 per cent of genetic factors can right now be identified and explained, a further 87 per cent of genetic influence remains unidentified, unexplained and untreatable. “So whatever the defect is,” said Dr. Silber, “it remains most likely that the ICSI patient will pass that defect on to the offspring. So far, we simply haven’t been able to identify the main causative gene.

A study presented in the same session by Dr. Simoni from the University of Munster found only seven cases of DAZ deletions in 130 azoospermic men (from a series of 316 infertile men). These were mostly in the region on the Y chromosome identified as AZFc (azoospermia factor c region).

No deletions were identified in men with sperm concentrations over lXl0^6/ml.

The rates of micro-deletions were 5.4 per cent in azoospermia, 2.4 per cent in oligozoospermia and 9.3 per cent in Sertoli cell only.

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