Infertile patients cannot afford to wait for treatment while their eggs get older.
Dr. Sherman Silber, Infertility Center of St. Louis, is offering free video consultations for patients who need to plan now for their treatment while stay-at-home orders are in place. He is talking to and evaluating patients in their home via to comply with social distancing measures.
Dr. Silber is discovering that patients actually prefer this method of telemedicine consultation over the conventional office visit. Patients have conveyed that “it is so much more convenient and less stressful” to have a free telemedicine personal consultation than to take a day off from work to travel to the doctor’s office and sit with other nervous patients in the waiting room.
The COVID-19 pandemic is thus changing much of the way we will do things in the future, and for the better. "Our patients are surprisingly much happier with this approach. Of course, at some point we need to perform hands on treatment. But with this new manner of seeing patients, we can come to the right diagnosis and treatment plan for most patients more efficiently, quickly, and painlessly, with no loss of personal one-on-one communication.” This is a very welcome new era of telemedicine that has been forced on us by the current difficult times.
To the Editor: We previously reported in the Journal a case of a successful ovarian transplantation between 25-year-old monozygotic twins. One had undergone menopause at the age of 14 years, whereas the other was still fertile.1 After receiving a graft of ovarian tissue from her sibling, the previously menopausal twin conceived spontaneously during the second menstrual cycle and delivered a healthy full-term baby. Subsequently, 10 other pairs of monozygotic twins who were discordant for ovarian failure sought consultation at our center for ovarian transplantation. Four women correspondence had previously failed to conceive after receiving donor eggs through in vitro fertilization (IVF), two also required surgery for fibroids or cysts, and all preferred the possibility of natural conception, the option to cryopreserve spare tissue for future use, and the advantage of undergoing a single procedure. We report on the outcomes of the seven twins who have already undergone ovarian transplantation.
All recipients had high follicle-stimulating hormone (FSH) levels and had had amenorrhea for 2 to 26 years (Table 1). In all cases of transplantation, ovarian graft tissue was obtained by unilateral oophorectomy, trimmed to approximately the same dimensions as the resected surface of the recipient ovarian medulla, and shaved to a thickness of approximately 1 mm to facilitate early revascularization. The medullary bed was sutured to the undersurface of the cortical graft with 9-0 sutures to maintain tight tissue approximation. All seven recipients resumed menses (range, 65 to 93 days after surgery), and by day 140 after transplantation, all had regular cycling, with a normal serum FSH level on day 3 of the menstrual cycle. There have been five pregnancies thus far (four were spontaneous and one was achieved through natural-cycle IVF), and the other women continue to have regular menstrual cycles, although after 2 years the FSH levels began to rise.
Genetically discordant premature ovarian failure in monozygotic twins is not as rare as we had previously assumed.2 Ten of the 11 cases that we have seen were apparently the result of congenital germ-cell deficiency, since histologic analysis verified the absence of primordial follicles and there were no other antecedent diseases or exposures associated with ovarian failure.3 Identical twins, like animal clones, are not actually identical, owing to epigenetic variations such as DNA methylation. Recipient 7 had had acute lymphoblastic leukemia more than 4 years before ovarian transplantation and had also received a bone marrow transplant (which is what caused her ovarian failure) from her sister, who has not had cancer. Unlike her sister, she also had a large nevus on her face. Recipient 5 had type 1 diabetes, whereas her twin had normal glucose levels but had a history of Graves’ disease. These are all diseases for which there is a recognized genetic predisposition4 and that were discordant in these monozygotic sisters.
The type of twinning was known for six of the pairs of monozygotic twins. Three of the six were monochorionic and monoamniotic (incidence, 50%), which is normally rare among twin pregnancies (incidence, 1 to 3%; P<0.005).5 This suggests that late splitting of embryos may be associated with discordant ovarian function, which could be due to either misallocation of early germ-cell precursors or increased epigenetic instability of genes regulating oogenesis.6
Our transplantation results should encourage continued efforts to bank ovarian tissue for patients with cancer, in anticipation of reimplantation after remission. More speculatively, these procedures could enable healthy women to extend their reproductive life span.
Sherman J. Silber, M.D. St. Luke’s Hospital St. Louis, MO 63017
Roger G. Gosden, Ph.D., D.Sc. Weill Medical College of Cornell University New York, NY 10021
Silber SJ, Lenahan KM, Levine DJ, et al. Ovarian transplantation between monozygotic twins discordant for premature ovarian failure. N Engl J Med 2005;353:58-63.
Gosden RG, Treloar SA, Martin NG, et al. Prevalence of premature ovarian failure in monozygotic and dizygotic twins. Hum Reprod 2006;22:610-5.
Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod 1992;7:1342-6.
Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006;7:21-33.
Su LL. Monoamniotic twins: diagnosis and management. Acta Obstet Gynecol Scand 2002;81:995-1000.
Weksberg R, Shuman C, Caluseriu O, et al. Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome. Hum Mol Genet 2002;11: 1317-25.