If you have any questions, you may call us at  (314) 576-1400.

Dr. Silber

Dr. Sherman J. Silber, M.D.

We intend for this site to provide you with solid, extensive information on the latest in infertility, and to provide some information about our center.

If you have any questions or would like even more information, please feel free to contact us.

To get feedback from patients who have undergone treatment at our Center, click here to go to the Patient Comments page.



Fertility can be readily restored, by thawing the frozen ovarian tissue and transplanting it back into the patient. It is not a difficult procedure for the doctor or for the patient. The tissue that was frozen is the outer membrane of the ovary, which is where all the eggs are located. It is placed back in the woman’s other non preserved ovary with very simple stitching. This tissue then comes to life and the ovary begins to function as though it had never been removed and frozen. The woman conceives naturally without any need for IVF.

The reason this technique works so robustly is that all the woman’s eggs are located not within the ovary, but on the outside capsule. So we are not really freezing and thawing the ovary. we are just freezing a thin piece of ovary tissue very much like a simple skin graft. Ovary transplantation therefore is an outpatient procedure that involves minimum pain, similar to the original ovary freeze.

See Articles and Videos to get a clearer picture of this very effective method of preserving your fertility.

Learn more about Ovarian Tissue Freezing

Learn more about Preserving Your Fertility

Learn more about Fertility Preservation for Cancer Patients 

TV News Coverage


Cancer patient Amy Tucker gives birth to her son, Grant Patrick, after her frozen ovarian tissue was transplanted by Dr. Silber – Fox Channel 2 St. Louis.


Cancer patient Amy Tucker becomes pregnant after her frozen ovarian tissue is transplanted by Dr. Silber- Fox Channel 2 St. Louis


News Video of freezing the biological clock; the new techniques for preserving a woman’s fertility indefin


Interview in 2011 with Amy Tucker whose ovary was frozen in 1997 as a young girl prior to undergoing sterilizing cancer treatment.



Woman without cancer preserves her fertility by freezing ovarian tissue.


Leukemia patient cured by bone marrow transplant from her sister as a 4 year old, 25 years later receives ovary transplant from her sister to restore her lost fertility – Fox Channel 2 St. Louis.


Print/Web News Coverage



St. Louis doctor helping women preserve chance at motherhood at no fees altruistically until the day when insurance will pay


Dr. Silber Performs First Ever Ovary Transplant in China.Read More


“America is leaps and bounds ahead of the UK when it comes to fertility treatment, particularly in the field of Ovarian Tissue Freezing…” Fertility Roadmagazine, March/April 2011.Read More


“Survivors Reach New Fertile Ground” LIVESTRONG Quarterly magazine, Summer/Fall 2011. Read More

The Wall Street Journal

New Way to Extend Fertility: Freeze Ovary Tissue Wall Street Journal; April 26, 2007


Cover story on The Riverfront Times: The Egg Man – Dr. Sherman Silber says he can extend a woman’s fertility by decades. He just needs to freeze her eggs or even a piece of her ovarian tissue; October 4, 2007


Successful Pregnancy after Microsurgical Transplantation of an Intact Ovary – Dr. Sherman Silber explains the technical side of the first successful ovary transplant.


High Doses of Hormones Faulted in Fertility Care – The New York Times
Read More


Cross-cultural Fertilization: Dr. Sherman Silber Takes His Reproductive Technology to China – St. Louis Magazine; August 2012
Read More


Fresh and Cryopreserved Ovary Transplantation and Resting Follicle Recruitment
June 1, 2015

Dr. Silber answers questions from national reporter about ovary freezing and egg freezing for cancer patients

“Multiple Sclerosis (MS) Patient” Dr. Silber’s Blog, September 18, 2012

“Women could delay the menopause indefinitely with ovary transplant: doctors” The Telegraph, July 4, 2012

“Ovarian Transplant” KTVI Channel 2 St. Louis, July 15, 2010

“Amy Tucker gives birth following ovary freezing and transplantation” KSDK St. Louis, July 16, 2010

“Dr.Silber helps cancer survivor have baby with frozen ovary” St. Louis Business Journal, July 16, 2010

“First U.S. cancer survivor gives birth after ovary freezing and transplant” St. Louis Globe-Democrat, July 16, 2010

“Having a Baby After Cancer” Women’s Health, June, 2010

“Ovarian Transplant Recipient Gives Birth Twice”WebMD.com, February 24, 2010

“Top 10 Medical Stories of 2008” ABC News; December 24, 2008

“Ovary-Transplant Birth Raises Fears” The Independent; November 16, 2008

Ovary Transplant Baby, “A Miracle” BBC News; November 15, 2008

“Baby Born After Ovary Transplant” BBC News; November 12, 2008

“Baby Due as Result of First Ever Whole Ovary Transplant”News-Medical; November 9, 2008

“Woman to Give Birth After Ovary Transplant Pregnancy”The Guardian; November 9, 2008

“Local doctor pioneers ovary transplants” St. Louis Post-Dispatch; February 12, 2007

Follow-up: Ovarian Transplantation between Monozygotic Twins Discordant for Premature Ovarian Failure New England Journal of Medicine; March 29, 2007

“Sisters’ Ovary Transplant Allows Conception After Cancer”ABC News March 1, 2007

“Ovary transplant recipient gives birth” St. Louis Post-Dispatch; June 8, 2005

Ovarian Transplantation between Monozygotic Twins Discordant for Premature Ovarian Failure (PDF, 301K) New England Journal of Medicine; June 7, 2005

“Woman Gives Twin Ovary for Transplant” AOL News; April 24, 2004

“Woman will get twin sister’s ovary” St. Louis Post-Dispatch; April 21, 2004

Technical Videos of Ovary Transplantation

Radio Interviews


Listen to Dr. Silber Talk About Ovary Freezing for Cancer Patients on KMOX, St. Louis, Missouri, October 18, 2012. (1:23 min)


Listen to Dr. Sherman Silber interviewed on syndicated national radio.
July 9, 2012. (7:12 min)


Listen to Dr. Sherman Silber explain on National Public Radio (NPR) all about how cancer patients can preserve their fertility.
November 2, 2009. (48:35 min)

Technical Articles of Ovary Transplantation

Ovarian Transplantation – Our Experience and Vision. Editorial by Dr. Sherman J. Silber, M.D. IVF NEWS.Direct!; April/June 2011

Duration of Fertility After Fresh and Frozen Ovary Transplantation Fertility and Sterility; February 19, 2010

Successful vitrification of bovine and human ovarian tissue
Reproductive BioMedicine Online; February 24, 2009

Successful Pregnancy after Microsurgical Transplantation of an Intact Ovary
New England Journal of Medicine; December 11, 2008

Oocyte vitrification—Women’s emancipation set in stone
Fertility and Sterility; April, 2008

A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation Human Reproduction; February 18, 2008

Follow-up: Ovarian Transplantation between Monozygotic Twins Discordant for Premature Ovarian Failure
New England Journal of Medicine; March 29, 2007

Ovarian Transplantation between Monozygotic Twins Discordant for Premature Ovarian Failure (PDF, 301K)
New England Journal of Medicine; June 7, 2005

See also: